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BRCA1 — PIK3CA

Text-mined interactions from Literome

Altiok et al., J Biol Chem 1999 (Breast Neoplasms) : In the absence of heregulin, the ectopic expression of the constitutively active p110 subunit of PI3K was sufficient to induce BRCA1 phosphorylation
Ibrahim et al., Cancer Discov 2012 (Breast Neoplasms) : PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple negative breast cancer to PARP inhibition ... We show in TNBC cells that PI3K inhibition leads to DNA damage, downregulation of BRCA1/2 , gain in poly-ADP-ribosylation, and subsequent sensitization to PARP inhibition