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SMPD1 — TNF
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
Acid Sphingomyelinase (SMPD1)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Acid Sphingomyelinase (SMPD1)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
Text-mined interactions from Literome
Barsacchi et al., Mol Pharmacol 2003
:
In contrast, although
acid sphingomyelinase was also
stimulated by
TNF-alpha , its inhibition was without effect
Heinrich et al., Cell Death Differ 2004
:
Cathepsin D links
TNF induced
acid sphingomyelinase to Bid mediated caspase-9 and -3 activation
Zeng et al., J Neurochem 2005
(Infection) :
Abeta,
TNF-alpha , or the combination of both,
increased neutral sphingomyelinase (nSMase) activity, but not
acidic sphingomyelinase (aSMase) activity, leading to ceramide accumulation
Schütze et al., Immunobiology 1995
:
The
aSMase activation by
TNF is secondary to the generation of 1,2-diacylglycerol ( DAG ) produced by a TNF-responsive PC-PLC