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EGR1 — IL4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lohoff et al., J Biol Chem 2010
:
Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 ( Th2 ) cells and is
involved in acute transcription of the Th2 cytokine
interleukin-4 ... We further investigate the
role of
Egr-1 in regulation of the Th2 cytokine
interleukin-4 (IL-4) expression ... Ectopic expression of
Egr-1 enhances endogenous
IL-4 mRNA expression and elevates IL-4 promoter activity ... We also show that
Egr-1 , nuclear factor of activated T cell, and NF-kappaB cooperatively bind to an NFAT/NF-kappaB overlapping IL-4 enhancer element and
activate the
IL-4 promoter synergistically
Klaus et al., Mol Immunol 1993
:
Effects of
IL-4 and Fc gamma receptor II engagement on
Egr-1 expression during stimulation of B lymphocytes by membrane immunoglobulin crosslinking
Liu et al., Cell Growth Differ 1993
(Carcinoma, Hepatocellular...) :
Other similar cytokines were investigated, and, of these, only
interleukin 1 could
increase both
Egr-1 and LDL receptor activity