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HSPG2 — RHOA

Text-mined interactions from Literome

Seifert et al., J Biol Chem 2004 : These results indicate that PLC-epsilon is a direct downstream effector for RhoA and that RhoA dependent activation of PLC-epsilon depends on a unique insert within the catalytic core of the phospholipase
Ochocka et al., Int J Biochem Cell Biol 2008 (Hypertension) : There is the data indicating that RhoA inhibits PLC-delta1 and factors downmodulating RhoA activate phospholipase
Seifert et al., J Biol Chem 2008 : Additive activation of PLC-epsilon by RhoA and K- or H-Ras was observed in intact cell studies, and this additivity was recapitulated in experiments in which activation of purified PLC-epsilon was quantified with PtdIns ( 4,5 ) P ( 2 ) -containing phospholipid vesicles reconstituted with purified, isoprenylated GTPases ... These results indicate that PLC-epsilon can be directly and concomitantly activated by both RhoA and individual Ras GTPases resulting in diverse upstream control of signaling cascades downstream of PLC-epsilon
Notcovich et al., Exp Cell Res 2010 : Our results reveal that functional coupling of the H1R to Gq-PLC leads to the activation of RhoA and Rac small GTPases and suggest distinct roles for Rho GTPases in the control of cell proliferation by histamine