Gene interactions and pathways from curated databases and text-mining

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JAK2 — TYK2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Doucet et al., Oncogene 2000 (Lung Neoplasms...) : In normal cells, we detected the activation of the classic IRS-2 or JAK1/STAT6 pathways, the phosphorylation of JAK2 , while Tyk2 was constitutively phosphorylated and not modified by both cytokines
Lukashova et al., J Immunol 2003 : Janus kinase 2 activation by the platelet activating factor receptor ( PAFR ) : roles of Tyk2 and PAFR C terminus ... Moreover, Tyk2-K930I completely blocked PAF stimulated Jak2 phosphorylation
Shang et al., Cancer Sci 2007 (Carcinoma, Renal Cell...) : The results suggest that the resistance of RCC to IFN-alpha is associated with the lack of Jak1, Tyk2 and Stat1 expression and defective Jak-Stat activation , but not with a lack of IFN-alpha receptor, suppressors of cytokine signaling induction or other factors examined
Simmons et al., J Virol 2009 : Furthermore, at times when STAT1 activation was efficiently inhibited, VRP infection did not limit tyrosine phosphorylation of Jak1, Tyk2 , or STAT2 after IFN-beta treatment but did inhibit Jak1 and Jak2 activation in response to IFN-gamma, suggesting that VEEV interferes with STAT1 activation by the type I and II receptor complexes through distinct mechanisms
Dedoni et al., J Neurochem 2010 (Neuroblastoma) : Janus kinase inhibition reduced IFN-ß stimulated TyK2 and STAT1 phosphorylation, STAT1 transcriptional activity, induction of double stranded RNA activated protein kinase ( PKR ) and caspase cleavage
Bhattacharjee et al., Free Radic Biol Med 2013 : We further show that Jak2 is upstream of Stat3 activation and Tyk2 controls Stat1 and Stat6 activation in response to IL-13 stimulation
Shuai et al., Nature 1993 : Somatic cell genetics experiments have demonstrated a requirement for tyrosine kinase-2 (Tyk2) in the IFN-alpha response pathway and for Jak2 ( ref. 6 ), a kinase with similar sequence, in the IFN-gamma response pathway
Murata et al., J Biol Chem 1995 (Colonic Neoplasms) : The phosphorylation of JAK1 and JAK2 was induced by IL-4 stimulation ; however, Tyk2 was constitutively phosphorylated, and IL-4 treatment further augmented this phosphorylation
Pan et al., Circ Res 1997 (Acute Disease...) : Both cilazapril ( angiotensin II-converting enzyme inhibitor ) and E4177 ( angiotensin II type 1 [ AT1 ] receptor antagonist ) significantly suppressed the phosphorylation of Tyk2 and partially inhibited the phosphorylation of JAK2 , but neither affected JAK1