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IL13 — TNF

Text-mined interactions from Literome

Luttmann et al., Am J Respir Cell Mol Biol 1999 : However, eosinophil viability and CD69 expression increased synergistically when eosinophils were incubated with IL-13 or IL-4 in the presence of TNF-alpha
Hart et al., Eur J Immunol 1999 : mRNA levels for IL-13R alpha1, but not IL-4R alpha, were markedly decreased in in vitro monocyte derived macrophages ( MDMac ), and with increasing time of monocytes in culture correlated with the loss of IL-13 regulation of lipopolysaccharide induced TNF-alpha production
De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4, tumor necrosis factor , or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Bailer et al., Eur J Immunol 2000 : We show that IL-13 in the presence of TNF-alpha effected an equal or greater antiviral activity against a dual-tropic HIV-1 ( R5X4 ) in macrophages
Paludan et al., Eur Cytokine Netw 2000 (Herpes Genitalis) : Even though IL-13 reduced TNF-alpha secretion by 50 %, this did not impair NF-kappa B activation in IFN-gamma treated cells infected with HSV-2
Ghigo et al., Infect Immun 2001 (Endocarditis, Bacterial...) : First, interleukin-10 suppressed C. burnetii stimulated production of TNF
Moore et al., Am J Physiol Lung Cell Mol Physiol 2002 (Asthma) : U-0126 also inhibited IL-13 , and TNF-alpha induced mRNA expression
Fernandes et al., Biorheology 2002 (Disease Models, Animal...) : Similarly, IL-13 significantly inhibits lipopolysaccharide (LPS) induced TNF-alpha production by mononuclear cells from peripheral blood, but not in cells from inflamed synovial fluid ... In OA synovial membranes treated with LPS, IL-13 inhibited the synthesis of IL-1beta, TNF-alpha and stromelysin, while increasing IL-1Ra production.In summary, modulation of cytokines that control MMP gene up-regulation would appear to be fertile targets for drug development in the treatment of OA
Lutz et al., J Immunol 2002 : In contrast, the production of IL-12 p70, but not IL-10 and TNF , induced by microbial products was enhanced only by IL-4, not by IL-13 or Y119D, a selective type II IL-4R agonist, in vitro and in vivo
Werth et al., J Invest Dermatol 2003 : Although interleukin-12 is considered to act primarily on lymphocytes, provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha, we hypothesized that interleukin-12 might also affect tumor necrosis factor alpha secretion from skin cells ... Remarkably, the exogenous interleukin-12 totally blocked ultraviolet-B induced tumor necrosis factor alpha production ... Thus, interleukin-12 strongly inhibits tumor necrosis factor alpha production by noninflammatory skin cells, mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter
Lin et al., Crit Care Med 2003 (Hyperoxia) : Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia + tumor necrosis factor-alpha induced leukocyte recruitment and subsequently tumor necrosis factor-alpha, interleukin-1 beta, and GRO/CINC-1 release
Xiao et al., J Dermatol Sci 2003 : Both IL-4 and IL-13 inhibit the TNF-alpha and IFN-gamma enhanced MDC production in a human keratinocyte cell line, HaCaT cells ... Both interleukin-4 (IL-4) and IL-13 inhibited TNF-alpha and IFN-gamma enhanced MDC production in HaCaT cells in a dose dependent manner
Jana et al., J Neurochem 2003 : Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages
Maeda et al., J Invest Dermatol 2003 : Among T helper 1 cytokines, interleukin-4 mediated suppression of tumor necrosis factor-alpha was not affected by terfenadine, which, however, markedly restored mRNA expression of interferon-gamma or interleukin-2
Nomura et al., J Immunol 2003 (Dermatitis, Atopic...) : We found that IL-13 and IL-4 inhibited TNF-alpha- and IFN-gamma induced HBD-3 production
Tada et al., Hokkaido Igaku Zasshi 1992 (Brain Neoplasms...) : TNF at a low dose ( 10 U/ml ) stimulated production of prostaglandin E2, Mn-superoxide dismutase, interleukin (IL)-6 and IL-8 by glioblastoma cells
Ichiyama et al., Inflamm Res 2004 : Moreover, the inhibitory effects of IVIG on IkappaBalpha degradation, interleukin-6 (IL-6) production, and E-selectin expression induced by TNF-alpha were evaluated by Western blot analysis, ELISA, and flow cytometry, respectively
Cheon et al., J Rheumatol 2004 (Arthritis, Rheumatoid...) : When RA FLS are stimulated with interleukin 1 or tumor necrosis factor-a , WISP3 mRNA is significantly increased
Desmet et al., Biochem Pharmacol 2005 : On the contrary, both RSG and TRO significantly potentiated TNF-alpha induced production of granulocyte/macrophage-colony stimulating factor, interleukin (IL)-6 and/or IL-8 in these cells
Van Damme et al., J Invest Dermatol 1990 : This study focuses on interferon-beta (IFN-beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha)
Albanesi et al., J Immunol 2007 : IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3
Choi et al., FEMS Immunol Med Microbiol 2007 (Candidiasis) : CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving tumor necrosis factor-alpha dependent interleukin-12 induction
Shembade et al., J Virol 2007 : Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and interleukin-1 mediated NF-kappaB activation
Hayes et al., Parasite Immunol 2007 (Trichuriasis) : TNF-alpha does increase transcription of both IFN-gamma and IL-13 in vitro but can also act synergistically with IL-13 in vitro to promote production of RELMbeta, which has also been shown to play a role in resistance to T. muris
Sethu et al., J Immunol 2008 (Calcium Signaling...) : Furthermore, use of antisense oligonucleotides to reduce expression of PLD1 or PLD2 demonstrated that PLD1 is required for TNF-alpha induced production of several important cytokines, such as IL-1beta, IL-5, IL-6, and IL-13 , in human monocytes
Hortobágyi et al., J Allergy Clin Immunol 2008 : TNF-alpha , elicited either by allergen exposure or pulmonary overexpression, induced SP-D, IL-13 , and mononuclear cell influx in the lung
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Tyagi et al., Mol Cell Endocrinol 2010 : In addition, like 17beta-estradiol, presence of medicarpin inhibited TNFalpha induced upregulation of interleukin-1 , and -6 mRNA levels in osteoblasts
Gutteberg et al., APMIS 1991 (Sepsis) : Using a whole blood in vitro model, we have investigated the effect of Escherichia coli ( E. coli ), Streptococcus agalactiae ( group B streptococci, GBS ) and tumor necrosis factor alpha (TNF) on the generation of lactoferrin (LF), interleukin-1 beta (IL-1) and tissue thromboplastin (TPL) in healthy newborns at term and their mothers
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1, tumor necrosis factor , and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Chan et al., Int J Oncol 1997 : Involvement of interleukin-1 in the differentiation inducing activity of tumor necrosis factor-alpha on a murine myeloid leukemia ( WEHI-3B JCS )
Carlo et al., J Pediatr 2011 (Cerebral Palsy...) : The analyses were focused on 5 cytokines ( interleukin [ IL] 1ß ; IL-8 ; tumor necrosis factor-a ; regulated upon activation, normal T-cell expressed, and secreted ( RANTES ) ; and IL-2 ) reported to be most predictive of CP in term and late preterm infants
Takeda et al., Int Immunopharmacol 2011 (Orthomyxoviridae Infections) : On day 2, tumor necrosis factor (TNF)-a production in BALF was also reduced significantly, but interferon-a, interleukin-12 , and interferon-? productions were augmented and natural killer ( NK ) cell activity was significantly elevated
Ma et al., J Pharmacol Sci 2012 : We also demonstrated that pretreatment of cells with this compound prevented TNF-a induced expression of NF-?B target genes, such as interleukin 6, interleukin 8, monocyte chemotactic protein 1, cyclooxygenase-2 and inducible nitric oxide
Villacres et al., J Infect Dis 2012 (HIV Infections...) : Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation
Gunaydın et al., J Pediatr Surg 2012 (Acute Lung Injury...) : Aspiration of gastrointestinal decontamination agents produced histopathologic changes, elevated levels of malondialdehyde and surfactant protein D, reduced levels of antioxidant enzymes, and increased expression of inflammatory cytokines interleukin-1ß and tumor necrosis factor a. Curcumin treatments effectively attenuated the rats ' pulmonary inflammation responses ( as shown by reduced alveolar damage ), decreased serum malondialdehyde and surfactant protein D levels, and inhibited the expressions of tumor necrosis factor a and interleukin-1ß
Souza et al., Br J Pharmacol 2013 : IL-4 and IL-13 inhibit IL-1ß and TNF-a induced kinin B1 and B2 receptors through a STAT6 dependent mechanism
Zhu et al., Journal of biomedical research 2010 : Recombinant IL-13 inhibited tumor necrosis factor-a (TNF-a) , IL-1a, IL-1ß, monocyte chemoattractant protein-1 ( MCP-1 ), IL-8, and transforming growth factor-ß1 ( TGF-ß1 ) mRNA expressions in a dose dependent manner
Elias et al., Am J Respir Cell Mol Biol 1990 : We determined whether normal human lung fibroblasts expressed cell associated thymocyte stimulating activity in response to recombinant interleukin-1 ( rIL-1 ) ( alpha and beta ) and recombinant tumor necrosis factor ( rTNF )
Tsukamoto et al., Inflamm Bowel Dis 2013 : : Enzyme linked immunosorbent assay and AP assay showed interleukin-1ß induced TNF-a shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells
Gowen et al., Endocrinology 1990 : Human osteoblast cultures derived as out-growths from trabecular bone released tumor necrosis factor ( TNF alpha ) upon stimulation of the cells with human recombinant interleukin 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ), human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ), and bacterial lipopolysaccharide ( 5-500 ng/ml )
Palladino et al., Ciba Found Symp 1987 (Neoplasms, Experimental) : Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of TNF-alpha or TNF-beta may involve the following biological activities : the induction of interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
Bachwich et al., Biochem Biophys Res Commun 1986 : Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages ... We have investigated the effect of tumor necrosis factor on the release of interleukin-1 and PGE2 from murine resident peritoneal macrophages ... Tumor necrosis factor causes an increase in the production of interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M
Hoffman et al., Lymphokine Res 1986 : The effects of tumor necrosis factor on the production of interleukin-1 by macrophages
Le et al., J Immunol 1987 : Induction of membrane associated interleukin 1 by tumor necrosis factor in human fibroblasts
Männel et al., Rev Infect Dis 1987 : No TNF induced production of interleukin 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures
Libby et al., Am J Pathol 1986 : Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells
Ferreira et al., Drugs 1993 (Hyperalgesia...) : The release of tumour necrosis factor-alpha (TNF-alpha) initiates the release of interleukin-1 and interleukin-8, which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines, respectively
Hart et al., Clin Exp Immunol 1995 (Arthritis...) : IL-13 significantly inhibited lipopolysaccharide (LPS) induced tumour necrosis factor-alpha (TNF-alpha) production by mononuclear cells from peripheral blood, but not synovial fluid
Benveniste et al., Int J Dev Neurosci 1995 : In this study, we demonstrate that transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-6 (IL-6) inhibit tumor necrosis factor-alpha expression by primary rat astrocytes
Tsuji et al., Am J Pathol 1995 (Granuloma...) : Thus, interleukin-1 alpha and inducible nitric oxide synthase were induced mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ), whereas tumor necrosis factor-alpha was induced in the cells around the beads at the later resolution phase ( 3 to 7 days )
Aggarwal et al., Exp Cell Res 1995 : Diminished responsiveness of senescent normal human fibroblasts to TNF dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF , and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Yano et al., J Leukoc Biol 1995 : IL-4, IL-10, and IL-13 suppressed the generation of antitumor activity and cytokine production ( IL-1 beta and TNF-alpha ) of monocytes stimulated with MCAF plus norMDP or LPS
de Waal Malefyt et al., J Immunol 1993 : Furthermore, IL-13 inhibited production of IL-1 alpha, IL-1 beta, IL-6, IL-8, IL-10, IL-12 p35, IL-12 p40, macrophage inflammatory protein-1 alpha, granulocyte/macrophage-CSF, granulocyte-CSF, IFN-alpha, and TNF alpha by monocytes activated with LPS
Doyle et al., Eur J Immunol 1994 : IL-13 markedly suppressed nitric oxide release and to a lesser extent secretion of the pro-inflammatory cytokine tumor necrosis factor-alpha
Seatter et al., Arch Surg 1994 (Disease Models, Animal) : Tumor necrosis factor and interleukin-1 regulation by lipopolysaccharide pretreatment
Blasi et al., Infect Immun 1994 : Moreover, pretreatment of macrophages with recombinant TNF for 3 h enhances TNF and induces interleukin-1 production in response to both forms of Candida, while pretreatment for 18 h renders macrophages refractory to any stimuli
Kambayashi et al., Cell Immunol 1996 : The inhibitory effect of IL-4 and IL-13 on the release of TNF alpha was partially reversed by neutralizing anti-IL10 antibody, and the inhibition of IL-6 release was completely reversed by the antibody
Becher et al., J Clin Invest 1996 : Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
Yamamoto et al., Eur J Pharmacol 1996 (Disseminated Intravascular Coagulation) : Plasma interleukin-1 and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) inhibited the increased plasma interleukin-1 ( 100.0 % ) and plasma TNF-alpha ( 89.2 % ) levels
Ortiz-Arduan et al., Am J Physiol 1996 (Endotoxemia) : Lipopolysaccharides (LPS), interleukin-1 beta, interferon-gamma (IFN-gamma), and TNF-alpha increase the levels of Fas mRNA in cultured mesangial and tubular cells
Lugli et al., J Biol Chem 1997 : Nevertheless, TNF-alpha stimulation led to increased activation of the IL-4-specific signal transducers and activators of transcription protein ( Stat6 ) by IL-4 and IL-13
Klegeris et al., Brain Res 1997 (Alzheimer Disease) : First, it was shown that THP-1 cells could be induced to secrete significant amounts of TNF-alpha by interleukin-1 , lipopolysaccharide, interferon-gamma (IFN-gamma) and PMA alone or in combination with each other
Kucharzik et al., Clin Exp Immunol 1996 (Colitis, Ulcerative...) : The inhibitory effect of IL-13 on TNF-alpha and IL-6 production in differentiated macrophages was diminished in IBD patients, as well as in controls
Mijatovic et al., J Biol Chem 1997 : The production of tumor necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS) stimulated macrophages can be markedly inhibited by the two closely related cytokines, interleukin (IL)-4 and IL-13
Di Santo et al., J Immunol 1997 : IL-13 inhibits TNF production but potentiates that of IL-6 in vivo and ex vivo in mice
Baumhofer et al., Eur J Immunol 1998 (Endotoxemia...) : Gene transfer with hIL-4 reduced the serum tumor necrosis factor (TNF)-alpha production in response to endotoxin/D-GalN by 80 % from 113.1 pg/ml in mock transfected animals to 22.2 pg/ml ( p < 0.05 ) ; human IL-13 gene transfer reduced serum TNF-alpha levels by 90 % ( 113.1 pg/ml to 11.6 pg/ml ; p < 0.05 )
Li et al., Eur J Pharmacol 1998 (Multiple Sclerosis) : Production of tumor necrosis factor-alpha and the lysosomal cysteine proteinase cathepsin B were markedly inhibited, but production of interleukin-1 increased
Jovanovic et al., Osteoarthritis Cartilage 1998 (Osteoarthritis) : We examined the effect of IL-13 on the synthesis and expression of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha) , IL-1 receptor antagonist (IL-1Ra) and stromelysin-1 on human OA synovial membrane in ex vivo cultures ... In addition, we explored the effect of IL-13 on both the IL-1 receptor (IL-1R) and TNF-receptor (TNF-R) systems on OA synovial fibroblasts ... In OA synovial membrane treated with LPS, IL-13 inhibited the synthesis of IL-1 beta, TNF-alpha and stromelysin-1, but increased IL-1Ra production
Bryson et al., Arch Biochem Biophys 1998 : It potently inhibited interleukin 1- and tumor necrosis factor stimulated proteoglycan release from both nasal and articular cartilage
Fiedler et al., Am J Respir Cell Mol Biol 1998 : The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit TNF-alpha induced nuclear factor-kappaB (NF-kappaB) activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells
Manna et al., J Immunol 1998 : The inhibitory effects of IL-13 on TNF were sensitive to H-7, neomycin, and wortmannin, suggesting that the pathway consisting of protein kinase C, phosphatidylinositol 3-kinase, and phospholipase C must be involved in IL-13 signaling
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Manna et al., J Biol Chem 1998 : IL-13 , which shares a common receptor subunit and various biological activities with IL-4, had no effect on TNF receptors
Lentsch et al., J Immunol 1999 (Acute Disease...) : In addition, anti-IL-13 caused significant increases in bronchoalveolar lavage levels of TNF-alpha , macrophage inflammatory protein-2, and cytokine-inducible neutrophil chemoattractant but no changes in lung vascular ICAM-1