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CTR9 — TNF

Text-mined interactions from Literome

Yamada et al., Eur J Pharmacol 1999 : However, exogenously added PAF up to 100 nM did not stimulate production of tumor necrosis factor-alpha
Alloatti et al., Cardiovasc Res 1999 : TNF-alpha in the presence of WEB 2170 or CV 3988, or PAF was studied with the Greiss reagent method
Dichmann et al., J Cell Physiol 2000 : The direct comparison between the two different protocols showed a slower decrease of PAF responsiveness induced by TNFalpha than by LPS
Alloatti et al., Am J Physiol Regul Integr Comp Physiol 2000 : TNF-alpha increased the production of PAF and NO
Fallani et al., Prostaglandins Other Lipid Mediat 2002 : Synthesis of PAF was not inducible by TNFalpha in murine F10-M3 melanoma cells
Young et al., Br J Pharmacol 2002 (Inflammation) : 7. The data indicate that firm adhesion and transmigration in mouse cremasteric venules stimulated by IL-1beta, but not TNFalpha , is protein synthesis dependent and mediated by endogenous generation of PAF and LTB ( 4 )
Mariano et al., Kidney Int 1992 (Peritonitis) : However, alpha 1-PI purified from patients with acute peritonitis was functionally inactive both on proteolytic activity on elastase and on TNF alpha induced PAF synthesis by purified human PMN
Matsumoto et al., Clin Exp Pharmacol Physiol 1992 (Respiratory Distress Syndrome, Adult) : 4. Furthermore, we investigated the priming effect of recombinant human tumour necrosis factor-alpha (TNF alpha) , which is known to be one of the most important mediators in the development of ARDS, on PAF production induced by the calcium ionophore in neutrophils
Buke et al., Med Princ Pract 2004 (Hepatitis B, Chronic) : The aim of this study was to determine tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) release in response to platelet activating factor (PAF) induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers ... Compared with group A, PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of TNF-alpha and IL-6 in response to PAF
Maier et al., J Surg Res 1992 : PAF alone had no effect on M phi PCA or TNF
Szappanos et al., Naunyn Schmiedebergs Arch Pharmacol 2005 : Finally, up to 2 mug/ml, PAF did not induce the production of pro-inflammatory cytokines such as IL-6, IL-8, and TNF-alpha
Rola-Pleszczynski et al., J Leukoc Biol 1992 (Leukemia, Promyelocytic, Acute) : Platelet activating factor (PAF) can augment tumor necrosis factor (TNF) production by human monocytes in a bimodal manner, with two peaks of activation at picomolar and micromolar concentrations ... Moreover, 6 day- or 7 day differentiated HL-60 cells showed a further increase in TNF production in response to PAF , and the response was bimodal, similar to that of the less dense subset of monocytes, with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF
Ruis et al., Lipids 1991 : PAF induced maximal TNF alpha synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody
Braquet et al., Lipids 1991 : The effect of platelet activating factor (PAF) and of two specific PAF antagonists on tumor necrosis factor (TNF) induced superoxide production by human polymorphonuclear neutrophils ( PMN ) was examined
De Plaen et al., Immunology 2006 : However, it remains elusive whether enterocytes release CXCL2 in response to LPS and TNF via a NF-kappaB dependent pathway and whether this involves the endogenous production of TNF and PAF
Sneddon et al., Biochim Biophys Acta 2006 : Both TNF-alpha and IL-1beta induced HUVEC platelet activating factor (PAF) production and PAF was required for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine )
Boetkjaer et al., Neurosci Lett 2007 (Encephalitis) : The data indicate that these three biochemically unrelated classes of inflammatory repressors act synergistically in modulating PAF induced up-regulation of COX-2, TNFalpha , and PGE ( 2 ) by quenching oxidative stress or inflammatory signaling, resulting in increased HN cell survival
Gountopoulou et al., Cytokine 2008 : Tumour necrosis factor alpha (TNFalpha) induces platelet activating factor (PAF) synthesis in many inflammatory cells ... We found that, although both cultures synthesized PAF at a similar basal rate, TNFalpha induced PAF synthesis in adipocytes was 7-fold higher than in preadipocytes ... Wortmannin enhanced TNFalpha dependent PAF synthesis in adipocytes but not in preadipocytes, indicating the negative control by PI3K in mature cells
Bauldry et al., J Immunol 1991 : We have further examined the effects of TNF-alpha on arachidonic acid ( AA ) release, LTB4 production, and platelet activating factor (PAF) formation in PMN by prelabeling cells with either [ 3H ] AA or [ 3H ] lyso-PAF, priming with human rTNF-alpha, and then stimulating with the chemotactic peptide, FMLP
Engelberts et al., Lymphokine Cytokine Res 1991 (Disease Models, Animal...) : Further, the role of PAF released in response to a challenge with LPS in the regulation of TNF and IL-6 production was investigated ... PAF played a central role in the TNF release in the in vitro experiments
Wolverton et al., Photochem Photobiol 2010 : Our previous studies have demonstrated that UVB mediated production of keratinocyte TNF-alpha is in part due to PAF
Kunze et al., Prostaglandins Other Lipid Mediat 2010 (Inflammation) : An immediate low release of PGE ( 2 ) was induced by PAF, phorbol ester and arachidonic acid but not by IL1beta, TNF-alpha and LPS whereas a delayed high release of PGE ( 2 ) was induced by the inflammatory agents IL1beta, TNF-alpha and LPS but not by PAF , phorbol ester and arachidonic acid
Sharif et al., J Ocul Pharmacol Ther 2010 : However, PAF did not stimulate the generation of IL-6, IL-8, TNF-alpha , and MMP-1 to any significant level and in a consistent manner
Spitzer et al., Innate Immun 2011 (Sepsis) : In rats, TNF-a increased hydraulic conductivity 2.5-fold over baseline and PAF increased it 5-fold ; but, pretreatment with CM-LPS or an attenuated analog ( CM-LPS* ) inhibited these changes
Bussolino et al., J Lipid Mediat 1990 : We compared the effect of purified recombinant human TNF alpha , TNF beta and IL-1 on the production of platelet activating factor (PAF) in HEC
Bonavida et al., J Lipid Mediat 1990 : Secretion of TNF was detected shortly after addition of PAF and was dependent on the PAF concentration used ... While biologically active and cytotoxic TNF was detected early after addition of PAF , the cytotoxic activity declined thereafter though the antigenic activity remained constant
Rola-Pleszczynski et al., J Lipid Mediat 1990 : We have recently shown that platelet activating factor (PAF) can markedly enhance the production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by human monocytes stimulated with lipopolysaccharide or muramyl dipeptide ( MDP )
Camussi et al., J Exp Med 1990 (Arthus Reaction) : The peptide HDMNKVLDL ( antiflammin-2 ) inhibits the synthesis of platelet activating factor (PAF) induced by TNF or phagocytosis in rat macrophages and human neutrophils, and by thrombin in vascular endothelial cells
Ferguson-Chanowitz et al., J Infect Dis 1990 (Shock, Septic) : The decrease in plasma TNF alpha induced by L-PAF or alprazolam was partly reversed by indomethacin
Camussi et al., Kidney Int 1990 : Inhibitors of PAF synthesis, such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide, blocked changes induced by TNF, PAF receptor antagonists inhibited changes induced by PAF and also by TNF
Rose et al., J Immunol 1990 : Methoxy-PAF increased cell associated TNF maximally after 2 to 3 h of incubation and increased TNF release maximally after 5 to 18 h of incubation
Dubois et al., J Immunol 1989 : Platelet activating factor (PAF) enhances tumor necrosis factor production by alveolar macrophages ... The effect of platelet activating factor (PAF) on TNF production by rat alveolar macrophages ( AM ) and the role of endogenous leukotriene B4 (LTB4) in this regulation were examined ... Stimulation of TNF production by PAF was blocked by specific, but structurally different PAF receptor antagonists, BN 52021, CV3988 and WEB 2086 ... Inhibition of 5-lipoxygenase by nordihydro-guaiaretic acid or AA-861 blocked the PAF induced augmentation of both TNF and LTB4 production ... Collectively, these data suggest that PAF enhances TNF production by interaction with a specific putative receptor and by subsequent induction of endogenous 5-lipoxygenase activity in AM
Chang et al., Am J Physiol 1989 : Since TNF stimulates PAF synthesis in vitro, we tested the hypothesis that PAF mediates TNF induced lung injury in vivo using specific PAF receptor antagonists
Camussi et al., J Exp Med 1988 : TNF and IL-1 stimulate the synthesis and release of platelet activating factor (PAF) by neutrophils and vascular endothelial cells ... Low concentrations of this antiproteinase and of human plasma alpha 1-antichymotrypsin inhibited TNF induced PAF synthesis in neutrophils, macrophages, and vascular endothelial cells
Camussi et al., J Exp Med 1987 : Synthesis of PAF in response to TNF was also detected in rat polymorphonuclear neutrophils, but not in human tumor cells and dermal fibroblasts
Bussolino et al., J Biol Chem 1988 : About 30 % of PAF produced in response to either TNF or IL-1 is released into the medium, whereas approximately 70 % remains cell associated ... Experiments with labeled precursors show that PAF is synthesized de novo in response to TNF ... This suggests that PAF is synthesized by the same pathway in response to TNF or IL-1
Sun et al., J Clin Invest 1988 (Disease Models, Animal...) : In the present study, we have shown that ( a ) TNF caused PAF production in bowel tissue ; ( b ) the effects of TNF and LPS on PAF production in the intestine are additive ; ( c ) TNF and LPS are synergistic in inducing bowel necrosis ; and ( d ) TNF induced bowel necrosis is due to PAF release and can be prevented by pretreatment with PAF antagonists
Montrucchio et al., J Exp Med 1994 (Neovascularization, Pathologic) : These results suggest that the angiogenic effect of TNF-alpha is, at least in part, mediated by PAF synthesized from monocytes and/or endothelial cells infiltrating the Matrigel plug
Schmid et al., Thromb Haemost 1995 : PAF , in turn, caused the production of TNF alpha and TNF beta, both of which are potent stimulators of TF expression
Howard et al., Cell Immunol 1995 (Neoplasms, Experimental) : In addition, PAF significantly enhanced LPS induced TNF alpha production
Weber et al., Eur J Immunol 1993 : In conclusion, the enhancement of PAF responses by TNF , associated with functional characteristics of differentiation in Mono Mac 6 cells, may represent a specific mechanism of cooperative interaction between PAF and TNF in inflammation, sepsis, immunoregulation and atherogenesis
Bussolino et al., Eur J Immunol 1994 : The generation of this elastase-like protein seems to be important for the synthesis of PAF induced by TNF-alpha and IL-1 alpha, as suggested by the following observations : ( a ) it precedes the synthesis of PAF ; ( b ) the inhibitors of serine protease and anti-human elastase antibody prevent the synthesis of PAF and the activation of 1-O-alkyl-2-lyso-glycerophosphocholine acetyl-CoA : acetyltransferase, which is a key enzyme of the PAF remodelling pathway ; ( c ) elastase, at concentrations similar to that detectable in the medium of cytokine activated EC, elicits a rapid synthesis of PAF by EC
Huang et al., Immunology 1994 (Necrosis...) : We have shown previously that endotoxin, tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury, and that endotoxin and TNF induce PAF formation in bowel tissue ... In the present study we investigated the effects of endotoxin and PAF on TNF gene expression
Huang et al., Exp Lung Res 1994 (Hypertension, Pulmonary...) : Because the release of PAF is stimulated by tumor necrosis factor (TNF) , this study was designed to measure the effects of polyI : C on TNF induced lung inflammation and injury
Sun et al., Dig Dis Sci 1995 (Necrosis...) : PAF also caused elevated serum TNF-alpha in some control mice but not in C3H/HeJ mice
Smith et al., J Immunol 1994 : Despite increasing RNA for the TNF-alpha gene, PAF increases TNF-alpha protein levels only in the presence of a costimulus, such as PMA ... We also report that PAF enhances PMA induced TNF-alpha production from human peripheral B cells
Ju et al., Yao Xue Xue Bao 1993 (Fibrosarcoma) : The results showed that PAF might play an important role in the production of TNF
Takata et al., Am J Pathol 1994 : Interleukin-1 beta and tumor necrosis factor-alpha induce PAF production by endothelium, and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist
Yokota et al., Eur J Pharmacol 1994 (Disseminated Intravascular Coagulation) : Furthermore, TNF production induced by PAF itself in vitro was also inhibited in the presence of FR128998
Ogata et al., Infect Immun 1993 (Shock, Septic) : It was concluded that PAF plays an important role in endotoxin induced TNF production and mortality
Gustafson-Svärd et al., Scand J Gastroenterol 1993 : In contrast to its effect on the AA turnover, TNF-alpha did not affect the phospholipase C-stimulated production of platelet activating factor ( PAF-acether )
Im et al., Cancer Res 1996 (Lung Neoplasms...) : The effect of platelet activating factor (PAF) on experimental pulmonary metastasis by the B16F10 murine melanoma and the possible involvement of PAF in the activities of tumor necrosis factor alpha (TNF-alpha) and interleukin 1alpha (IL-1alpha) in tumor metastasis were investigated
Denizot et al., Eur Cytokine Netw 1996 : We have assessed whether PAF stimulates IL-6 and TNF-alpha production by human bone marrow stromal cells ( mostly fibroblast-like cells )
Greenberg et al., Alcohol Clin Exp Res 1996 (Alcoholic Intoxication...) : BN-50730 inhibited PAF induced APCD and plasma TNF alpha
Frostegård et al., Arterioscler Thromb Vasc Biol 1997 : Both PAF and oxLDL induced tumor necrosis factor-alpha (TNF-alpha) synthesis in peripheral blood ... PAF mediated TNF-alpha production was inhibited by WEB 2170, whereas oxLDL induced TNF-alpha was only partially inhibited
Lacasse et al., Inflammation 1997 (Inflammation) : GM-CSF production by EC was also stimulated by the combined effects of PAF and TNF alpha , but PAF alone did not affect GM-CSF production
Im et al., Eur J Immunol 1997 : These data suggest that PAF , which is released immediately or shortly after LPS injection, induces the expression of TNF-alpha through the activation of NF-kappa B
Lo et al., Arch Surg 1997 : Furthermore, inhibiting PAF production with AACOCF3, or manoalide, also inhibited LPS induced Mphi TNF mRNA expression
Lou et al., Am J Respir Crit Care Med 1998 (Asthma...) : In summary, PAF induces goblet cell hyperplasia and TNFalpha potentiates this effect