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CD40 — RABEPK
Text-mined interactions from Literome
Aicher et al., J Immunol 1999
:
SB203580 strongly blocked
CD40 induced IL-12
p40 production in DCs at both mRNA and protein levels, while having minimal effect on CD40 induced expression of the chemokine RANTES
Möttönen et al., Arthritis Res 2002
(Arthritis, Rheumatoid) :
CD40 ligation
induced the secretion of
IL-12p40 but not IL-12p70
van Seventer et al., J Neuroimmunol 2002
(Multiple Sclerosis) :
We now describe how pre-incubation with 1000 U/ml of IFN-beta differentially regulates expression of multiple IL-12 family members in activated, immature human DC, inhibiting
CD40/IFN-gamma induced p35 and
p40 message levels, while enhancing p19 and Epstein-Barr virus induced gene 3 (EBI3) levels
Kelsall et al., Ann N Y Acad Sci 1996
(Colitis) :
Finally, we show that IL-10 has a potent capacity to shut down
CD40 induced IL-12
p40 secretion ; and, in addition, IL-4 partially inhibits CD40 induced IL-12 p40 secretion and enhances IL-10 mediated inhibition in an additive fashion
Yoshimoto et al., Eur J Immunol 1997
:
Induction of interleukin-12
p40 transcript by
CD40 ligation via activation of nuclear factor-kappaB