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PCNA — ZC3H12D
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Klingler-Hoffmann et al., Eur J Cell Biol 2005
:
Two different substrates were offered : the phospho-peptide KR(p)TIRR and histone H1 phosphorylated by means of the
cyclin dependent protein kinase
p34 ( cdc2 )
Meijer et al., EMBO J 1991
:
Several observations point to an extremely close association between accumulation of unphosphorylated cyclin and p34cdc2 tyrosine phosphorylation : ( i ) both events coincide perfectly during the G2 phase ; ( ii ) both tyrosine phosphorylated p34cdc2 and cyclin are not immunoprecipitated by anti-PSTAIR antibodies ; ( iii ) accumulation of unphosphorylated
cyclin by aphidicolin treatment of the cells,
triggers a dramatic accumulation of tyrosine phosphorylated
p34cdc2 ; and ( iv ) inhibition of cyclin synthesis by emetine inhibits p34cdc2 tyrosine phosphorylation without affecting the p34cdc2 concentration
Forsburg et al., Nature 1991
:
At G2-M,
p34cdc2 kinase activity in S. pombe
requires a B-type
cyclin in a complex with p34cdc2 ; this complex is the same as MPF ( maturation promoting factor ) ... The
p34cdc2 activity at the G1-S transition in S. cerevisiae may be
regulated by a similar
cyclin complex, using one of the products of a new class of cyclin genes ( CLN1, CLN2 and WHI1 ( DAF1/CLN3 ) )
Atherton-Fessler et al., Mol Biol Cell 1994
:
In cells of higher eukaryotic organisms the activity of the
p34cdc2/cyclin B complex is
inhibited by phosphorylation of
p34cdc2 at two sites within its amino-terminus ( threonine 14 and tyrosine 15 )
Banerjee et al., Oncogene 1994
:
We also show that p300 can be used as a substrate for the
cyclin dependent p33cdk2 and
p34cdc2 kinases, and propose that E1A might be antagonistic to these enzymes in phosphorylating p300
Stewart et al., EMBO J 1994
:
In contrast,
cyclin B1 does not
require p34cdc2 binding for specific proteolysis
Rowley et al., Int J Radiat Biol 1996
:
The activity of
p34cdc2 in G2 is
regulated by phosphorylation and association with a B-type
cyclin , the product of the cdc13 gene, p56cdc13
Audit et al., Biol Cell 1996
:
In the fission yeast Schizosaccharomyces pombe, only one
cyclin , the product of the cdc13 gene ( p56cdc13 ), is
required to be associated with
p34cdc2 , to control the complete cell cycle