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IL12B — IRF3

Text-mined interactions from Literome

Liu et al., J Exp Med 2003 : Thus, IRF-1 acts as a critical component of IFN-gamma signaling in the selective activation of IL-12 p35 transcription in synergy with LPS mediated events
Lehtonen et al., Cytokine 2003 : Both IFN-alpha and IL-12 strongly up-regulated IRF-1, IRF-4 , and IRF-8 mRNA and protein expression
Xiong et al., J Biol Chem 2005 : Furthermore, IRF-8 induced IL-12 p40 synthesis in RAW264.7 cells was enhanced by dominant negative Cbl, and peritoneal macrophages from Cbl-/- mice showed increased IL-12 p40 protein production
Goriely et al., Blood 2006 : Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3 induced IL-12p35 gene activation ... Since IL-12p35 mRNA was induced in human DCs activated through TLR3 or TLR4 but not TLR2, we investigated the potential role of interferon regulatory factor 3 (IRF-3) in IL-12p35 gene transactivation ... Finally, experiments on DCs from IRF-3-deficient mice established that TLR4 induced IL-12p35 mRNA and IL-12p70 synthesis are impaired in absence of IRF-3
Aksoy et al., Blood 2007 : Because IRF-3 activity is also required for IL-12p70 synthesis, our findings provide a molecular basis for the decreased ability of LPS stimulated neonatal moDCs to elicit Th1-type responses