Gene interactions and pathways from curated databases and text-mining

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BRAF — YWHAB

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sutor et al., J Biol Chem 1999 : Although IL-3 did not activate B-Raf , A-Raf was activated by the cytokine
MacNicol et al., J Biol Chem 1999 : The kinase domains of Raf-1 and B-Raf are highly conserved, and it has been predicted that B-Raf catalytic activity would also be inhibited by PKA
MacNicol et al., J Biol Chem 2000 : Expression of the isolated B-Raf catalytic domain (B-Rafcat) induces PC12 cell differentiation in the absence of nerve growth factor
Blanquet et al., Neuroscience 2000 : Our results suggest that : ( i ) extracellular signal regulated kinase is activated by B-Raf in response to a calcium-sensitive adenylate cyclase ; and ( ii ) extracellular signal regulated kinase activates casein kinase-2 via a protein phosphatase ( s ) that may be of the PP1 and/or PP2A type
Antonelli et al., Mol Biol Cell 2000 : In Chinese hamster ovary cells, EGF receptors activate B-Raf but not Raf-1 or A-Raf
Guan et al., J Biol Chem 2000 : Furthermore, expression of Akt inhibits epidermal growth factor induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo ... Furthermore, expression of Akt inhibits epidermal growth factor induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo
Piiper et al., Mol Pharmacol 2000 : In contrast, PTx , CCK, and EGF had only minor effects on A-Raf and B-Raf activity ... In contrast, PTx, CCK , and EGF had only minor effects on A-Raf and B-Raf activity ... In contrast, PTx, CCK, and EGF had only minor effects on A-Raf and B-Raf activity
York et al., Mol Cell Biol 2000 : PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras, since both rapid ERK activation and the Ras dependent activation of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either PI3-K or endocytosis ... PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras, since both rapid ERK activation and the Ras dependent activation of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either PI3-K or endocytosis
Garcia et al., Mol Cell Biol 2001 : Indeed, ( i ) in cells expressing wild-type or mutant Mpl, TPO induced Ras and Rap1 activation correlates with early and sustained phases of ERK signal, respectively ; ( ii ) interfering mutants of Ras and Rap1 both inhibit ERK kinase activity and ERK dependent Elk1 transcriptional activation in response to TPO ; ( iii ) the kinetics of activation of Raf-1 and B-Raf by TPO follow those of Ras and Rap1, respectively ; ( iv ) RasV12 mediated Elk1 activation was modulated by the wild type or interfering mutants of Raf-1 but not those of B-Raf ; ( v ) Elk1 activation mediated by a constitutively active mutant of Rap1 ( Rap1V12 ) is potentiated by B-Raf and inhibited by an interfering mutant of this kinase
Mikula et al., EMBO J 2001 : MEK/ERK activation is normal in Raf-1-deficient cells and embryos, and is probably mediated by B-RAF
Zhang et al., J Biol Chem 2001 : These results indicate that B-Raf kinase activity is negatively regulated by Akt and SGK , suggesting that the cross-talk between the B-Raf and other signaling pathways can be mediated by both Akt and SGK ... These results indicate that B-Raf kinase activity is negatively regulated by Akt and SGK, suggesting that the cross-talk between the B-Raf and other signaling pathways can be mediated by both Akt and SGK
Banihashemi et al., Mol Endocrinol 2002 : TRH induced c-Raf but not B-Raf activation, and the D2S receptor inhibited both TRH induced c-Raf and basal B-Raf kinase activity ... TRH induced c-Raf but not B-Raf activation, and the D2S receptor inhibited both TRH induced c-Raf and basal B-Raf kinase activity ... TRH induced c-Raf but not B-Raf activation, and the D2S receptor inhibited both TRH induced c-Raf and basal B-Raf kinase activity
Nadal-Wollbold et al., FEBS Lett 2002 : Platelet ERK2 activation by thrombin is dependent on calcium and conventional protein kinases C but not Raf-1 or B-Raf
Carey et al., J Biol Chem 2003 : In contrast to Raf-1, B-Raf is activated by Rap1
Gendron et al., J Biol Chem 2003 : In the present report, we demonstrate that activation of the AT(2) receptor rapidly, but transiently, activated the Rap1/B-Raf complex of signaling proteins
Dillon et al., J Biol Chem 2003 : Recent studies suggest that Rap1 can activate the MAP kinase kinase kinase B-Raf that is either endogenously or ectopically expressed
Troppmair et al., Oncogene 1992 : We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate induced activation of Raf-1 kinase in NIH3T3 cells and Raf-1 as well as B-Raf PSK stimulation by nerve growth factor (NGF) in PC12 pheochromocytoma cells
Karbowniczek et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR) independent
Chadee et al., Nat Cell Biol 2004 : MLK3 is required for mitogen activation of B-Raf , ERK and cell proliferation ... Our results define an unexpected role for MLK3 in mitogen regulation of B-Raf , ERK and cell proliferation
Yamaguchi et al., J Biol Chem 2004 (Polycystic Kidney Diseases) : In M-1 cells, we showed that calcium restriction was associated with an elevation in B-Raf protein levels and cAMP stimulated, Ras dependent activation of B-Raf and ERK
Chadee et al., Cell cycle (Georgetown, Tex.) 2004 : A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation ... These results define a new role for MLK3 in B-Raf activation, ERK signaling and cell proliferation
Tanami et al., Oncogene 2004 (Melanoma...) : Not only downregulation of the endogenously overexpressed wild-type B-Raf by antisense oligonucleotide but also a treatment with an inhibitor of mitogen activated protein kinase kinase ( MAPKK, MEK ) reduced phosphorylated ERK1/2 and cell growth, whereas the exogenously expressed wild-type B-Raf promoted cell growth in MM cells
Mizuchi et al., Biochem Biophys Res Commun 2005 : BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells ... BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells
Akula et al., Blood 2005 (Herpesviridae Infections...) : In addition, B-Raf induced VEGF-A expression was demonstrated to be sufficient to enhance tubule formation in endothelial cells
Trakul et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Because c-Raf-1 and B-Raf are both required for maximal MAPK stimulation by epidermal growth factor in neuronal and epithelial cell lines, we determined whether RKIP significantly affects MAPK signaling
Dwivedi et al., Mol Psychiatry 2006 (MAP Kinase Signaling System) : Our results of selective reduction in catalytic activity and expression of B-Raf but not Raf-1 suggest that B-Raf may be playing an important role in altered ERK signaling in brain of suicide subjects, and thus in the pathophysiology of suicide
Sétáló et al., Neurochem Res 2005 : While direct activation of PKC mimicked the effect of estrogen on ERK, both in pattern of activation and resulting intraneuronal distribution of ERK, PKC induced ERK phosphorylation required the activity of MEK but not B-Raf
Burger et al., Eur Urol 2006 (Microsatellite Instability...) : The present study investigated B-RAF mutations, MSI status, and activation of MAPK signaling in prostate tumors
Yue et al., Oncogene 2006 : No changes in the activity of B-Raf were detectable during progesterone induced oocyte maturation, after egg fertilization, or during the early embryonic cell cycle, arguing against a role for B-Raf in the mitotic activation of MEK1 and p42 MAPK ... No changes in the activity of B-Raf were detectable during progesterone induced oocyte maturation, after egg fertilization, or during the early embryonic cell cycle, arguing against a role for B-Raf in the mitotic activation of MEK1 and p42 MAPK ... We found that both B-Raf and C-Raf, but not Mos, are required for Ras induced MEK1 and p42 MAPK activation ... We found that both B-Raf and C-Raf, but not Mos, are required for Ras induced MEK1 and p42 MAPK activation
Calipel et al., J Biol Chem 2006 (Cell Transformation, Neoplastic...) : This ruled out a role for Rap1 in the PKA mediated B-Raf/ERK activation in ( WT ) B-Raf cells ... This ruled out a role for Rap1 in the PKA mediated B-Raf/ERK activation in ( WT ) B-Raf cells ... Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity, ERK1/2 activation, and cell proliferation in ( WT ) B-Raf cells, whereas it did not affect ( V600E ) B-Raf cells, demonstrating a key role of PKA in mediating ( WT ) B-Raf/ERK signaling for uveal melanoma cell growth
Wang et al., Mol Cell Biol 2006 : Rap1 activation by Epac-CAAX, but not wild-type Epac, triggers its association with B-Raf
Karhoff et al., Neuroendocrinology 2007 (Digestive System Neoplasms...) : Overexpression of Rap1 and B-Raf activated MAPK extracellular dependent kinase (ERK) ERK-2 and ERK dependent transcription factor Elk-1 in neuroendocrine cell lines Bon and INS-1 ... Overexpression of Rap1 and B-Raf activated MAPK extracellular dependent kinase (ERK) ERK-2 and ERK dependent transcription factor Elk-1 in neuroendocrine cell lines Bon and INS-1
Willard et al., EMBO J 2007 : Here, we show that RGS12 associates with the nerve growth factor (NGF) receptor tyrosine kinase TrkA , activated H-Ras, B-Raf , and MEK2 and facilitates their coordinated signaling to prolonged ERK activation ... Here, we show that RGS12 associates with the nerve growth factor (NGF) receptor tyrosine kinase TrkA, activated H-Ras, B-Raf , and MEK2 and facilitates their coordinated signaling to prolonged ERK activation
Fu et al., Yi Chuan 2007 (Stomach Neoplasms) : B-RAF-siRNA significantly inhibited the expression of B-RAF gene and Bcl-2 gene in BGC823 cells by more than 90 % to 100 % ... In conclusion, B-RAF-siRNA can effectively inhibit the expression of B-RAF gene and Bcl-2 gene, induce cell apoptosis and inhibit the proliferation of gastric cancer BGC823 cells ... In conclusion, B-RAF-siRNA can effectively inhibit the expression of B-RAF gene and Bcl-2 gene, induce cell apoptosis and inhibit the proliferation of gastric cancer BGC823 cells
Ren et al., Proc Natl Acad Sci U S A 2007 : Our data identify a previously unrecognized interaction between IQGAP1 and B-Raf and suggest that IQGAP1 is a scaffold necessary for activation of B-Raf by EGF
Hao et al., Mol Cancer Ther 2007 (Colorectal Neoplasms...) : These observations suggest that inhibition of B-Raf activation of mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase ( MEK ) and the extracellular signal regulated kinase MAPK cascade may be an effective approach for the treatment of RAS and B-RAF mutation positive melanomas and colon carcinomas
Chen et al., J Neurochem 2008 : Not unexpectedly, expression of active B-Raf inhibits the apoptosis associated increase in ATF-3 expression ... Like GW5074, RNA dependent protein kinase inhibitor, SK4 , and SK6 all inhibited c-Raf in vitro but activated B-Raf in neuronal cultures
Yue et al., Dev Neurobiol 2008 : Artificial Erk activation by expression of constitutively active Mek1 and B-Raf failed to block ephrin-A5 effects on growth cones, and inhibitors of the Erk pathway also failed to inhibit collapse by ephrin-A5
Zheng et al., Mol Cell 2009 (Melanoma) : Here, we show that AMPK activation is suppressed in melanoma cells with the B-RAF V600E mutation and that downregulation of B-RAF signaling activates AMPK
Vuchak et al., Mol Pharmacol 2009 (MAP Kinase Signaling System) : Silencing the expression of B-Raf also inhibited ERK activation by TSH, forskolin, and 6MB-cAMP, but not that stimulated by insulin or serum ... Silencing the expression of B-Raf also inhibited ERK activation by TSH, forskolin, and 6MB-cAMP, but not that stimulated by insulin or serum
Hu et al., Pigment Cell Melanoma Res 2010 (Melanoma) : Furthermore, alphaB-crystallin is down-regulated in a B-RAF dependent manner in melanoma cells and its re-expression regulates cyclin D1 turnover after DNA damage
Abel et al., Cancer Res 2010 (Melanoma) : These studies show that FOXD3 is suppressed by B-RAF , uncover a novel role and mechanism for FOXD3 as a negative cell cycle regulator, and have implications for the repression of melanocytic lineage cells
Perera et al., Arthritis Res Ther 2010 (Inflammation) : However, IL-1beta activated B-Raf kinase activity ... However, IL-1beta activated B-Raf kinase activity
Shao et al., Cancer Res 2010 (Melanoma) : Importantly, myristylated Akt3 prevented B-RAF targeting induced upregulation of Bim-EL and Bmf in three-dimensional collagen and partially protected Mcl-1 depleted cells from apoptosis
Yamaguchi et al., American journal of physiology. Renal physiology 2010 (Polycystic Kidney, Autosomal Dominant) : We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK , inhibited cAMP dependent activation of B-Raf and MEK/ERK signaling, and caused a concentration dependent inhibition of cell proliferation induced by cAMP, epidermal growth factor, or the combination of the two agonists ... We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK, inhibited cAMP dependent activation of B-Raf and MEK/ERK signaling, and caused a concentration dependent inhibition of cell proliferation induced by cAMP, epidermal growth factor , or the combination of the two agonists
Karki et al., J Biol Chem 2011 (Melanoma) : Because treatment with the kinase inhibitor sorafenib decreased NHE1 activity in HeLa and HEK cells, we examined the role of B-Raf in regulating NHE1 in malignant melanoma cells
Fecteau et al., Mol Med 2012 (Leukemia, Lymphocytic, Chronic, B-Cell) : One single dose of 10 µmol/L or the repeated addition of 1 µmol/L sorafenib caused caspase dependent apoptosis and reduced levels of phosphorylated B-RAF , C-RAF, extracellular signal regulated kinase ( ERK ), signal transducer and activator of transcription 3 ( STAT3 ) and myeloid cell leukemia sequence 1 (Mcl-1) in CLL cells in the presence of the microenvironment
Shao et al., Cell death & disease 2012 : In this study, we show that Bmf is regulated at the post-translational level by mutant B-RAF-MEK-ERK2 signaling
Satoh et al., PloS one 2012 (Genetic Predisposition to Disease...) : However, ( T599A ) B-RAF did not destabilize the inactive conformation of the B-RAF kinase, and did not induce increased ERK phosphorylation or C-RAF transactivation
Röring et al., EMBO J 2012 (MAP Kinase Signaling System) : In contrast, B-Raf ( wt ) and Raf-1 ( wt ) mediated signalling triggered by oncogenic Ras as well as the paradoxical activation of Raf-1 by kinase inactivated B-Raf require an intact DIF. Surprisingly, the B-Raf DIF is not required for dimerisation between Raf-1 and B-Raf, which was inactivated by the D594A mutation, sorafenib or PLX4720
Boyd et al., J Invest Dermatol 2013 (Melanoma...) : Most prominent was the B-RAF mediated transcriptional repression of E-cadherin , a keratinocyte-melanoma adhesion molecule whose loss is intimately associated with melanoma invasion and metastasis ... Most prominent was the B-RAF mediated transcriptional repression of E-cadherin , a keratinocyte-melanoma adhesion molecule whose loss is intimately associated with melanoma invasion and metastasis ... We show that B-RAF ( V600E ) induces the expression of Tbx3 , which potently represses E-cadherin expression in melanocytes and melanoma cells
Bonfiglio et al., Mol Endocrinol 2013 : B-Raf and CRHR1 Internalization Mediate Biphasic ERK1/2 Activation by CRH in Hippocampal HT22 Cells ... B-Raf and CRHR1 Internalization Mediate Biphasic ERK1/2 Activation by CRH in Hippocampal HT22 Cells
Hong et al., Exp Cell Res 2013 (MAP Kinase Signaling System...) : Using androgen deprived LNCaP cells, in which ERK1/2 activation occurs in strong correlation with AKT activation, we found that AKT mediated B-Raf regulation is necessary for ERK1/2 activation ... Using androgen deprived LNCaP cells, in which ERK1/2 activation occurs in strong correlation with AKT activation, we found that AKT mediated B-Raf regulation is necessary for ERK1/2 activation
Eychène et al., Oncogene 1995 (Leukemia) : We also show that both p95B-raf and p72B-raf can be activated by IL-3 in murine BAF-3 pro-B cells and by anti-CD3 in human Jurkat cells, respectively
Peraldi et al., FEBS Lett 1995 : Regulation of the MAP kinase cascade in PC12 cells : B-Raf activates MEK-1 ( MAP kinase or ERK kinase ) and is inhibited by cAMP ... Hence, these data indicate that the PKA mediated phosphorylation of B-Raf hampers its interaction with p21ras, which is responsible for the PKA mediated decrease in B-Raf activity
Ohtsuka et al., J Biol Chem 1996 : Here we have used this assay system and examined the effect of Rap1 on the B-Raf activity to phosphorylate recombinant MAP kinase kinase ( MEK )
Knall et al., J Biol Chem 1996 : Surprisingly, wortmannin, at low concentrations, inhibits Raf-1, B-Raf , and MAPK activation in response to IL-8 and C5a demonstrating a role for phosphatidylinositol 3-kinase in the activation of Raf kinases in G protein coupled receptor systems in human neutrophils
Vossler et al., Cell 1997 : These cell type-specific actions of cAMP require the expression of the serine/threonine kinase B-Raf and activation of the small G protein Rap1
Tombes et al., Biochem J 1998 : In contrast to hepatocytes, NGF treatment of PC12 pheochromocytoma cells caused large sustained activations of B-Raf and p42 ( MAPkinase ), and a lower phasic activation of Raf-1
Denis-Henriot et al., Endocrinology 1998 : Wild-type Galpha12 overexpression prevented the decrease in MAPK activity and induced MEK1, but not B-Raf , expression ... Wild-type Galpha12 overexpression prevented the decrease in MAPK activity and induced MEK1, but not B-Raf , expression