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MYC — TMED7
Text-mined interactions from Literome
Bergmann et al., Int J Cancer 2001
(Neuroblastoma) :
In culture, activation of
MYC induces both sequestration of
p27 ( kip1 ) by cyclin D complexes and its subsequent proteolytic degradation
Gartel et al., Exp Cell Res 2003
(Cell Transformation, Neoplastic) :
Myc suppresses expression of cell cycle/growth arrest genes gas1, p15, p21,
p27 , and gadd34, -45, and -153
Chandramohan et al., J Immunol 2004
:
Ectopic
c-Myc blocked the induction of
p27 expression upon either inhibition of PI3K or BCR engagement ... Thus,
p27 ( Kip1 ) is coordinately
regulated via two arms of a signaling pathway that are inversely controlled upon inhibition of PI3K : induction of the activator FOXO3a and down-regulation of the repressor
c-Myc
Mack et al., Mol Cell Biol 2005
(Fibrosarcoma) :
The transcription of p21 and
p27 is
inhibited by
c-Myc ; therefore, the induction of CKIs was attributed to the ability of HIF to antagonize c-Myc activity
Acosta et al., Mol Cell Biol 2008
(Leukemia) :
Microarray based gene expression indicated that, in the presence of
p27 ,
Myc blocked the upregulation of several erythroid-cell-specific genes, including NFE2, JUNB, and GATA1 ( transcription factors with a pivotal role in erythropoiesis )
Bagui et al., Cell cycle (Georgetown, Tex.) 2009
:
PDGF increased the expression of c-Myc in the absence but not presence of a histone deacetylase inhibitor, and
c-Myc inhibited
p27 ( Kip1 ) promoter activity when ectopically expressed in fibroblasts
Old et al., Mol Cancer Res 2010
(Cell Transformation, Neoplastic...) :
As expected,
Myc mediated suppression of
p27 ( Kip1 ) was abolished in Skp2-null Emu-Myc B cells
Bretones et al., J Biol Chem 2011
(Leukemia...) :
Moreover, silencing of SKP2 abrogated the
MYC mediated down-regulation of
p27 ... Our data show that SKP2 is a direct MYC target gene and that
MYC mediated SKP2 induction
leads to reduced
p27 levels
Müller et al., Oncogene 1997
:
Activation of
Myc triggers a rapid induction of cyclin E/cdk2 kinase activity and degradation of
p27 ...
Myc induced release of
p27 from cdk2 requires cdk2 kinase activity and is delayed in a T187V mutant of p27