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IGF1 — PTK2

Text-mined interactions from Literome

Tai et al., Cancer Res 2003 (Multiple Myeloma) : In addition, IGF-I triggers polymerization of F-actin, induces phosphorylation of p125(FAK) and paxillin, and enhances beta1 integrin interaction with these focal adhesion proteins
Hunter et al., Ciba Found Symp 1985 (Cell Transformation, Viral) : IGF I and insulin, whose receptors also have ligand stimulated protein-tyrosine kinase activity, induce p42 phosphorylation in appropriate cells
Costrici et al., Endocrinology 1995 : A cytosolic protein tyrosine kinase activity is induced by follicle stimulating hormone and insulin like growth factor-I in human granulosa cells
Chen et al., Carcinogenesis 1995 : Insulin-like growth factor-I (IGF-I) stimulated the activity of membrane protein tyrosine kinase ( s ) ( PTK ) in both normal and DES treated hamster kidneys ... To understand the mechanism of activation of IGF-I dependent PTK by DES, we investigated the relationship between the binding capacity of IGF-I to membrane proteins and the level of IGF-IR ... These findings suggest that an enhanced level of IGF-IR coupled with qualitative changes may be responsible for the activation of IGF-I dependent PTK on DES exposure ... These findings suggest that an enhanced level of IGF-IR coupled with qualitative changes may be responsible for the activation of IGF-I dependent PTK on DES exposure
Vig et al., J Neurol Sci 1994 (Nerve Degeneration...) : We examined insulin-like growth factor I (IGF-I) dependent phosphorylation and protein tyrosine kinase ( PTK ) activity in cerebellar cortex of normal humans, patients with olivopontocerebellar atrophy ( OPCA ) ( `` C '' kindred ) and in lurcher mutant mouse, a suggested animal model for OPCA
Narayan et al., Cancer Res 1993 (Kidney Neoplasms) : IGF-1 stimulated normal kidney or tumor membrane protein tyrosine kinase ( s ) ( wheat germ lectin agarose purified membrane proteins ) in a dose dependent fashion ... Therefore, the alteration of IGF-1 binding activity of the tumor membrane receptors and stimulation of IGF-1 mediated membrane protein tyrosine kinase activity in tumor tissues suggest that events coupled to this membrane receptor may play a role in estrogen stimulation of renal carcinoma
Hishinuma et al., Endocr J 1994 (Cystadenoma, Papillary...) : This study shows that stimulation of the protein tyrosine kinase activity by basic FGF, EGF, and IGF-1 promoted DNA replication by the human thyroid cancer cell line
Casamassima et al., J Biol Chem 1998 : IGF-I induced p130 ( Cas ), p125(Fak) , and paxillin tyrosine phosphorylation could be dissociated from mitogen activated protein kinase kinase, p70 ( S6K ), and protein kinase C activation ... In contrast, the structurally unrelated phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 markedly attenuated the increase in tyrosine phosphorylation of p130 ( Cas ), p125(Fak) , and paxillin induced by IGF-I ... Thus, our results identified a phosphatidylinositol 3-kinase dependent pathway that requires the integrity of the actin cytoskeleton to induce tyrosine phosphorylation of p130 ( Cas ), p125(Fak) , and paxillin in response to IGF-I and suggest that tyrosine phosphorylation of these focal adhesion proteins, together with the recruitment of c-Crk into a complex with p130 ( Cas ), may play a novel role in IGF-I signal transduction