Gene interactions and pathways from curated databases and text-mining

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IGF1 — ITGAV

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: ITGAV → IGF1 (increases)
    Evidence: Treatment of HT29-D4 cells with antibodies to alphaV, alpha-6 and beta-1 integrins significantly inhibited the des (1-3)-IGF1 (analogue of IGF-1) induced cell migration. Incubation with a mixture containing anti-alphaV, anti-alpha6 and anti-beta1antibodies together totally abolished migration, indicating that these integrin subunits are involved in the IGF-1 induced cell migration.
  • NCI Pathway Database Integrins in angiogenesis: IGF1 (IGF1) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
    Kuemmerle et al., Am J Physiol Gastrointest Liver Physiol 2006
    Evidence: assay, physical interaction

Text-mined interactions from Literome

Imai et al., Endocrinology 1999 : Our previous studies have shown that IGF-I increases the affinity of the alphaVbeta3 integrin toward ligands and that occupancy of this integrin is indispensable for IGF-I to stimulate cell migration
Maile et al., Endocrinology 2002 : The alphaVbeta3 integrin regulates insulin-like growth factor I (IGF-I) receptor phosphorylation by altering the rate of recruitment of the Src-homology 2-containing phosphotyrosine phosphatase-2 to the activated IGF-I receptor
Maile et al., Sci Transl Med 2010 (Atherosclerosis...) : We tested whether alpha(V)beta(3) integrin activation was increased in diabetic animals and whether an antibody to beta ( 3 ) would inhibit IGF-1 action and development of atherosclerosis
Doerr et al., J Biol Chem 1996 (Breast Neoplasms) : We conclude that : 1 ) IGF-I stimulates migration of these two cell types through the IGF-I receptor ; 2 ) interaction of vitronectin with the alpha v beta 5 integrin or collagen with the alpha 2 beta 1 integrin is necessary for the complete IGF-I response in MCF-7 cells, and 3 ) because migration represents an in vitro model for metastatic spread, integrins, extracellular matrix proteins, and IGF-I may play coordinated roles in the metastasis of breast cancer in vivo