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NOS3 — PTGS2

Text-mined interactions from Literome

Lomnitski et al., Pharmacol Toxicol 2000 (Liver Diseases) : Effects of apocynin and natural antioxidant from spinach on inducible nitric oxide synthase and cyclooxygenase-2 induction in lipopolysaccharide induced hepatic injury in rat
Chen et al., Br J Pharmacol 2003 : Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages
Ishimura et al., Am J Physiol Gastrointest Liver Physiol 2004 : Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth
Rigas et al., Trends Mol Med 2004 (Neoplasms) : Mechanistically, NO-aspirin, the best studied NO-NSAID, has pleiotropic effects on cell signaling ( it inhibits Wnt signaling, induces nitric oxide synthase and NF-kappaB activation and induces cyclooxygenase-2 expression ), and this mechanistic redundancy might be central to its mode of action against cancer
Clark et al., Biochem J 2005 (Inflammation) : PGHS-2 ( prostaglandin H synthase-2 ) is induced in mammalian cells by pro-inflammatory cytokines in tandem with iNOS [ high-output ( ` inducible ' ) nitric oxide synthase ], and is co-localized with iNOS and nitrotyrosine in human atheroma macrophages
Rodriguez et al., Am J Physiol Heart Circ Physiol 2006 : In addition, we conclude that the activation of mitogen activated protein kinases p42/p44, protein kinase C, and nitric oxide synthase is necessary for the increase in COX-2 levels induced by BK because either of the specific inhibitors for these enzymes blocked the effect of BK. Using a similar approach, we further demonstrated that reactive oxygen species and cAMP were not mediators on this pathway
Datta et al., Nephrol Dial Transplant 2006 (Disease Models, Animal...) : Regulatory effects of inducible nitric oxide synthase on cyclooxygenase-2 and heme oxygenase-1 expression in experimental glomerulonephritis
Chen et al., Eur J Pharmacol 2006 : We show that dipyridamole inhibited interleukin-6 and monocyte chemoattractant protein-1 secretion, inducible nitric oxide synthase protein expression, nitrite accumulation, and cyclooxygenase-2 (COX-2) induction in lipopolysaccharide (LPS) activated RAW 264.7 macrophages
Ramana et al., Circulation 2006 (Cardiomyopathies...) : These changes were associated with decreased myocardial nuclear factor-kappaB and activating protein-1 activity, prostaglandin E2 production, induction of cyclooxygenase 2 , and inducible nitric oxide synthase
Liao et al., Toxicol Lett 2009 : Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI(3)K-Akt-eNOS dependent cyclooxygenase-2 expression in endothelial cells
Ohtsu et al., Oncol Rep 2010 (Carcinoma, Squamous Cell) : Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2
Resta-Lenert et al., Am J Physiol Gastrointest Liver Physiol 2011 : Reduction of endogenous MUC17 is associated with increased permeability, inducible nitric oxide synthase and cyclooxygenase 2 induction , and enhanced bacterial invasion in response to EIEC exposure
Wu et al., Journal of neuroinflammation 2012 (Disease Models, Animal...) : Neuroinflammation in RVLM was also associated with a COX-2 dependent downregulation of endothelial nitric oxide synthase and an upregulation of intercellular adhesion molecule-1
Obermajer et al., Transplantation research 2012 : We observed that PGE2 induces endogenous cyclooxygenase (COX)2 expression in cultured monocytes, blocking their differentiation into CD1a+ dendritic cells (DCs) and inducing the expression of indoleamine 2,3-dioxygenase 1, IL-4Ra, nitric oxide synthase 2 and IL-10 - typical MDSC associated suppressive factors
Huang et al., Chem Res Toxicol 2013 : LK also reduced hippocampus injury by enhancing eNOS expression and remarkably inhibited the proinflammatory NF?B/iNOS/COX-2 signaling activity
Pang et al., Eur J Pharmacol 1996 : Induction of cyclooxygenase and nitric oxide synthase in endotoxin activated J774 macrophages is differentially regulated by indomethacin : enhanced cyclooxygenase-2 protein expression but reduction of inducible nitric oxide synthase