Gene interactions and pathways from curated databases and text-mining

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IL17A — IRF6

Text-mined interactions from Literome

Yang et al., Cancer Res 2009 (Lymphoma, B-Cell...) : Blockade of CD27-CD70 or CD28-CD80/86 interactions by anti-CD70 or anti-CD80/86 antibodies restored LPS mediated induction of IL-17 expression in CD4 ( + ) T cells cocultured with lymphoma B cells
Hueber et al., J Immunol 2010 (Arthritis, Rheumatoid) : Furthermore, we demonstrated in vitro that mast cells produced RORC dependent IL-17A upon stimulation with TNF-alpha, IgG complexes, C5a, and LPS
Mudter et al., Inflamm Bowel Dis 2011 (Colitis...) : In contrast to DSS colitis, IRF4 deficiency was protective in T-cell dependent transfer colitis associated with reduced RORa/?t levels and impaired IL-6, IL-17a , and IL-22 production, suggesting that IRF4 acts as a master regulator of mucosal Th17 cell differentiation
Park et al., Cytokine 2012 : LPS induced IL-17 and IL-23 upregulation was attenuated by pretreatment with inhibitors of phosphoinositide 3-kinase (PI3K), p38, extracellular signal regulated kinase ( ERK ), c-Jun N-terminal kinase (JNK), mitogen activated protein kinase ( MAPK ), and NF-?B, as well as neutralizing antibodies against Toll-like receptors ( TLRs ) 2 and 4
Higaki et al., Clin Exp Allergy 2012 (Eosinophilia...) : Staphylococcal enterotoxin B induced IL-5, IL-13, IL-17A and IFN-? production by DNPCs. Pre-treatment with LPS prior to SEB stimulation inhibited production of these cytokines
Carrión et al., Neuroimmunomodulation 2013 : Results : TNFa, LPS and poly ( I:C ) induced an increase in IL-17RA in RA-FLS, whereas TNFa, TNFa plus IL-17 and poly ( I:C ) enhanced IL-17RC transcripts in FLS