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GIP — GIPR

Pathways - manually collected, often from reviews:

• Reactome Reaction: GIPR → GIP (direct_complex) Bollag et al., Endocrinology 2000*, Moody et al., FEBS Lett 1984*, Volz et al., FEBS Lett 1995*
• Reactome Reaction: GIPR → GIP (reaction) Bollag et al., Endocrinology 2000*, Wenzel-Seifert et al., Biochem Pharmacol 2002, Zhang et al., Eur J Pharmacol 2003, Lambert et al., Science signaling 2008, Mitsuhashi et al., J Biol Chem 1989, Kozasa et al., Proc Natl Acad Sci U S A 1988, Moody et al., FEBS Lett 1984*, Volz et al., FEBS Lett 1995*, Baker et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: GIPR — GIP (direct interaction, x-ray crystallography) Parthier et al., Proc Natl Acad Sci U S A 2007*
• IRef Dip Interaction: GIPR — GIP (direct interaction, circular dichroism) Parthier et al., Proc Natl Acad Sci U S A 2007*
• IRef Dip Interaction: GIPR — GIP (direct interaction, isothermal titration calorimetry) Parthier et al., Proc Natl Acad Sci U S A 2007*
• IRef Hprd Interaction: GIPR — GIP (in vivo) Manhart et al., Biochemistry 2003*, Yamada et al., Horm Metab Res 2004*, Volz et al., FEBS Lett 1995*, Gallwitz et al., Regul Pept 1996*

Text-mined interactions from Literome

Yaqub et al., Mol Pharmacol 2010 : These data represent an important step toward understanding activation of GIPR by GIP , which should facilitate the rational design of therapeutic agents
Kim et al., Diabetes 2013 : Blunted GIP responsiveness in Retn ( +/- ) and Retn ( -/- ) adipocytes was therefore largely due to the greatly reduced GIPR expression associated with decreased c-Jun mediated transcriptional activation of Gipr
Tseng et al., Mol Cell Endocrinol 1998 : Recent studies have shown that elevated serum GIP level in diabetic patients may induce chronic desensitization of the GIP-R , and that this mechanism could contribute to impaired insulin secretion