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BRCA1 — SMC3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
SMC3 (SMC3)
(modification, activates)
Luo et al., J Biol Chem 2008
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
BRCA1
→
SMC3
(indirect_complex)
Garcia-Cruz et al., Reprod Biomed Online 2009, Scully et al., Cell 1997
-
Reactome Reaction:
BRCA1
→
SMC3
(reaction)
Ward et al., J Biol Chem 2001, Garcia-Cruz et al., Reprod Biomed Online 2009, Scully et al., Cell 1997
Text-mined interactions from Literome
Kitagawa et al., Genes Dev 2004
(Chromosome Aberrations) :
Here, we show that NBS1 and
BRCA1 are required for the recruitment of previously activated ATM to the sites of DNA breaks after ionizing irradiation, and that this recruitment is
required for the phosphorylation of
SMC1 by ATM
Antoccia et al., Radiat Res 2008
(Chromosome Aberrations...) :
It is noted that
BRCA1 is
required for the interaction of NBS1 with
SMC1 , whereas the reverse is not the case, since BRCA1 is able to bind to NBS1 in the absence of an NBS1/SMC1 interaction as observed in MRE11- or RAD50-deficient cells ... Our results reveal that ATM plays a fundamental role in promoting the radiation induced interaction of NBS1 with
SMC1 in the
presence of
BRCA1 , leading to the maintenance of chromosomal integrity
Fukuda et al., PLoS Genet 2012
:
We investigated the genetic requirements for the phosphorylation events and revealed that the phosphorylation levels of HORMAD1, HORMAD2, and SMC3 are dramatically reduced in the absence of initiation of meiotic recombination, whereas
BRCA1 and SYCP3 are
required for normal levels of phosphorylation of HORMAD1 and HORMAD2, but not of
SMC3