◀ Back to TNF
ITPR1 — TNF
Text-mined interactions from Literome
Park et al., J Biol Chem 2008
(Calcium Signaling...) :
Herein, we describe a novel neuron-intrinsic pathway in which the expression of the type-1
inositol 1,4,5-trisphosphate receptor is
regulated by the potent pro-inflammatory cytokine
tumor necrosis factor-alpha
Park et al., J Biol Chem 2009
(Inflammation...) :
Tumor necrosis factor-alpha mediated regulation of the
inositol 1,4,5-trisphosphate receptor promoter
Xia et al., FEBS Lett 2012
(Bone Resorption...) :
We found that
TNF-a increased the expression of IP3R1 and promoted osteoclastogenesis in RANKL induced mouse BMMs. Phosphatidylcholine-specific phospholipase C ( PC-PLC ) specific inhibitor D609 eliminated the upregulation of
IP3R1 by TNF-a, and decreased the autoamplification of nuclear factor of activated T-cells 1 ( NFATc1 ), thus resulted in less osteoclasts formation