Gene interactions and pathways from curated databases and text-mining

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IL10 — RNF19A

Text-mined interactions from Literome

Williams et al., J Interferon Cytokine Res 2000 : Synthesis of IL-10 in response to PGE2 is dependent on p38 MAP kinase activity, whereas synthesis of IL-6 is not
Ma et al., J Biol Chem 2001 : The p38 mitogen activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide stimulated human macrophages
Nagano et al., Int Immunol 2002 : Taken together, these results suggest that both ERK and p38 ( MAPK ) pathways are involved in LPS induced COX-2 expression and PGE ( 2 ) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down regulating the activation of p38 ( MAPK )
Hall et al., J Cell Biochem 2002 (MAP Kinase Signaling System) : Thus, we speculate that during inflammatory conditions in vivo macrophage p38 may regulate JNK and ERK activity and inhibit IL-10 expression
Feito et al., Eur J Immunol 2003 (MAP Kinase Signaling System) : ERK or JNKinhibitors partially inhibited IL-4 and IL-10 secretion, while PKC or p38 inhibitors had no significant effects on IL-4 or IL-10 secretion
Mathur et al., Nat Med 2004 (MAP Kinase Signaling System) : ERK-1/2 inhibition or IL-10 neutralization restores CD40 induced p38MAPK activation and parasite killing in macrophages and the BALB/c mouse, a susceptible host
Veiopoulou et al., Neuroimmunomodulation 2004 (MAP Kinase Signaling System) : IL-2 and IL-10 production by human CD4+T cells is differentially regulated by p38 : mode of stimulation dependent regulation of IL-2
Zhang et al., J Leukoc Biol 2011 (Inflammation...) : This production of IL-10 is mediated by CaMKIa dependent regulation of p38 MAPK activation
Koscsó et al., J Immunol 2012 (MAP Kinase Signaling System) : In addition, adenosine augmented IL-10 production by stimulating p38 MAPK
Bebien et al., PLoS Pathog 2012 (Streptococcal Infections) : Isogenic mutant bacteria lacking ßh/c fail to activate p38 mediated IL-10 production in macrophages and promote increased IL-12 and NOS2 expression
Katholnig et al., J Immunol 2013 : p38a signaling in myeloid immune cells promoted IL-10 but inhibited IL-12 expression via mTOR and blocked the differentiation of proinflammatory CD4 ( + ) Th1 cells