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IL10 — RNF19A
Text-mined interactions from Literome
Williams et al., J Interferon Cytokine Res 2000
:
Synthesis of
IL-10 in response to PGE2 is
dependent on
p38 MAP kinase activity, whereas synthesis of IL-6 is not
Ma et al., J Biol Chem 2001
:
The
p38 mitogen activated kinase pathway
regulates the human
interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide stimulated human macrophages
Nagano et al., Int Immunol 2002
:
Taken together, these results suggest that both ERK and
p38 ( MAPK ) pathways are involved in LPS induced COX-2 expression and PGE ( 2 ) production in neutrophils, and
IL-10 and IL-4
inhibit neutrophil prostanoid synthesis by down regulating the activation of p38 ( MAPK )
Hall et al., J Cell Biochem 2002
(MAP Kinase Signaling System) :
Thus, we speculate that during inflammatory conditions in vivo macrophage
p38 may regulate JNK and ERK activity and
inhibit IL-10 expression
Feito et al., Eur J Immunol 2003
(MAP Kinase Signaling System) :
ERK or JNKinhibitors partially inhibited IL-4 and IL-10 secretion, while PKC or
p38 inhibitors
had no significant effects on IL-4 or
IL-10 secretion
Mathur et al., Nat Med 2004
(MAP Kinase Signaling System) :
ERK-1/2 inhibition or
IL-10 neutralization
restores CD40 induced
p38MAPK activation and parasite killing in macrophages and the BALB/c mouse, a susceptible host
Veiopoulou et al., Neuroimmunomodulation 2004
(MAP Kinase Signaling System) :
IL-2 and
IL-10 production by human CD4+T cells is differentially
regulated by
p38 : mode of stimulation dependent regulation of IL-2
Zhang et al., J Leukoc Biol 2011
(Inflammation...) :
This production of
IL-10 is
mediated by CaMKIa dependent regulation of
p38 MAPK activation
Koscsó et al., J Immunol 2012
(MAP Kinase Signaling System) :
In addition, adenosine
augmented IL-10 production by stimulating
p38 MAPK
Bebien et al., PLoS Pathog 2012
(Streptococcal Infections) :
Isogenic mutant bacteria lacking ßh/c fail to activate
p38 mediated
IL-10 production in macrophages and promote increased IL-12 and NOS2 expression
Katholnig et al., J Immunol 2013
:
p38a signaling in myeloid immune cells
promoted IL-10 but inhibited IL-12 expression via mTOR and blocked the differentiation of proinflammatory CD4 ( + ) Th1 cells