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MADCAM1 — TNF
Text-mined interactions from Literome
Connor et al., J Leukoc Biol 1999
(Acute Disease...) :
No significant constitutive nor
TNF-alpha induced expression of
MAdCAM-1 was detected in skeletal muscle, brain, or heart ... In IL-10-deficient ( IL-10 k/o ) mice with no clinical or histological evidence of colitis, constitutive and
TNF-alpha induced expression of
MAdCAM-1 in the intestine, cecum, and colon was not different from those values obtained with healthy wild-type controls ... Taken together, these data demonstrate that
TNF-alpha enhances surface expression of
MAdCAM-1 in intestinal and colonic tissues to the same extent in both wild-type and IL-10 k/o mice with no colonic inflammation, whereas IL-10 k/o mice with active colitis exhibited a profound up-regulation of MAdCAM-1 in the colon
Oshima et al., Aliment Pharmacol Ther 2001
(Inflammatory Bowel Diseases) :
To examine how agents currently used to treat inflammatory bowel disease affect
MAdCAM-1 :
induced by
tnf-alpha in an in vitro model of inflammatory bowel disease ... Either dexamethasone or IL-10 : reduced
TNF-alpha induced
MAdCAM-1 : protein, mRNA and lymphocyte adhesion
Oshima et al., BMC gastroenterology 2001
(Inflammatory Bowel Diseases) :
TNF-alpha induced endothelial
MAdCAM-1 expression is regulated by exogenous, not endogenous nitric oxide ... DETA-NO, a long acting NO donor, and SperNO, a rapid releasing NO donor both inhibited
TNF-alpha stimulated
MAdCAM-1 expression in a concentration dependent manner ... Inhibition of endogenous NO production by either L-NAME, a non-selective NOS inhibitor, or by 1400 w, a selective iNOS inhibitor failed to induce, or potentiate
TNF-alpha regulated
MAdCAM-1 expression
Oshima et al., Am J Physiol Cell Physiol 2001
(Inflammatory Bowel Diseases...) :
We used two endothelial lines [ bEND.3 ( brain ) and SVEC ( high endothelium ) ] to study the signal paths that regulate
MAdCAM-1 expression in
response to
tumor necrosis factor (TNF)-alpha using RT-PCR, blotting, adhesion, and immunofluorescence
Sasaki et al., BMC gastroenterology 2002
:
Melatonin reduces
TNF-a induced expression of
MAdCAM-1 via inhibition of NF-kappaB ... We examined how different doses of melatonin reduced endothelial
MAdCAM-1 induced by
TNF-a in an in vitro model of lymphatic endothelium ...
MAdCAM-1 was
induced by
TNF-a
Sasaki et al., BMC gastroenterology 2003
(Inflammatory Bowel Diseases) :
A human IL-10 expression vector was transfected into high endothelial venular ( ` HEV ' ) cells ( SVEC4-10 ) ; we then examined
TNF-alpha induced lymphocyte adhesion to lymphatic endothelial cells and TNF-alpha induced expression of
MAdCAM-1 and compared these responses to control monolayers ... IL-10 transfected endothelial cells expressed less than half ( 46 +/- 6.6 % ) of the
MAdCAM-1 induced by
TNF-alpha ( set as 100 % ) in non transfected ( control ) cells
Lindholm et al., Infect Immun 2004
:
Furthermore, we show that
MAdCAM-1 can be
induced on human endothelial cells by
tumor necrosis factor alpha (TNF-alpha) and gamma interferon
Sasaki et al., Am J Physiol Cell Physiol 2004
(Lymphoma...) :
We show in this study that two cytochrome p-450 ( CYP450 ) inhibitors from Citrus paradis ( grapefruit ), bergamottin, and 6',7'-dihydroxybergamottin ( DHB ) block
tumor necrosis factor (TNF)-alpha stimulated expression of
MAdCAM-1 in cultured endothelial cells and also reduce alpha ( 4 ) beta ( 7 ) -dependent lymphocyte adhesion ... Bergamottin ( 20-50 microM ) or DHB ( 10-30 microM ) pretreatment dose-dependently reduced
TNF-alpha mediated expression of
MAdCAM-1 and lymphocyte adhesion ... SKF-525a, a specific CYP450 inhibitor, also blocked the expression of
MAdCAM-1 mediated by
TNF-alpha
Sasaki et al., BMC physiology 2005
:
We found that troglitazone ( 10-40 microM ), significantly reduced the
TNF-alpha ( 1 ng/ml ) mediated
induction of endothelial
MAdCAM-1 in a dose dependent manner, achieving a 34.7 % to 98.4 % reduction in induced MAdCAM-1
Ando et al., Inflamm Bowel Dis 2005
(Second Messenger Systems) :
TNF-alpha induced
MAdCAM-1 in a dose dependent manner by 24 hours ... In vitro,
MAdCAM-1 can be
induced on colon endothelial cells by
TNF-alpha stimulation and may represent a useful model to study microvascular injury in the large intestine
Ando et al., Lymphat Res Biol 2005
:
SV-LEC also expresses
MAdCAM-1 in
response to
TNF-alpha , an effect seen in VEC, but not AEC
Ando et al., BMC physiology 2007
:
Time and dose dependent expression of
MAdCAM-1 in
response to
TNF-alpha , IL-1 beta and IFN-gamma was studied by immunoblotting
Mizushima et al., Am J Physiol Gastrointest Liver Physiol 2010
(Colitis) :
Blockage of angiotensin II type 1 receptor regulates
TNF-alpha induced
MAdCAM-1 expression via inhibition of NF-kappaB translocation to the nucleus and ameliorates colitis ... AT1R blocker significantly suppressed
MAdCAM-1 expression
induced by
TNF-alpha , but did not inhibit phosphorylation of p38 MAPK or of IkappaB that modulate MAdCAM-1 expression
Liaskou et al., Hepatology 2011
(Cholangitis, Sclerosing...) :
In this study, we show that deamination of methylamine ( MA ) by vascular adhesion protein 1 (VAP-1) [ a semicarbazide-sensitive amine oxidase ( SSAO ) expressed in the human liver ] in the
presence of
tumor necrosis factor a induces the expression of functional
MAdCAM-1 in hepatic endothelial cells and in intact human liver tissue ex vivo
Biancheri et al., Inflamm Bowel Dis 2013
(Crohn Disease) :
As tumor necrosis factor alpha (TNF)-a, a cytokine centrally involved in CD, modulates gut endothelial adhesion molecules, we here explored the in vivo and ex vivo
effects of
TNF-a blockade on
MAdCAM-1 expression in CD
Takeuchi et al., Proc Natl Acad Sci U S A 1995
:
Expression of
MAdCAM-1 is
induced in the murine endothelial cell line bEnd.3 by
tumor necrosis factor alpha (TNF-alpha) , interleukin 1, and bacterial lipopolysaccharide ... These findings establish that, as with other endothelial cell adhesion molecules, transcriptional
induction of
MAdCAM-1 by
TNF-alpha requires activated NF-kappa B proteins
Ettinger et al., Int Immunol 1998
:
Splenic
MAdCAM-1 expression, follicular dendritic cell localization and normal Peyer 's patch development all
require both surface LT-alphabeta and
TNF activity