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EGFR — TNF
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Perez et al., Oncogene 1999
:
Prior to the onset of apoptosis,
TNF caused a significant reduction in the level of EGFr tyrosine phosphorylation in Sen cells but
mediated only limited suppression of
EGFr tyrosine phosphorylation in apoptotically resistant Res cells
Takeyama et al., Proc Natl Acad Sci U S A 1999
(Hyperplasia) :
We found that a MUC5AC inducing epithelial cell line, NCI-H292, expresses EGF-R constitutively ;
EGF-R gene expression was
stimulated further by
tumor necrosis factor alpha (TNFalpha)
Burgel et al., J Allergy Clin Immunol 2000
(Hyperplasia...) :
TNF-alpha immunoreactivity, expressed in eosinophils, was increased in EGFR positive polyps compared with EGFR negative polyps, suggesting a
role for
TNF-alpha in
EGFR expression
Hirota et al., J Biol Chem 2001
:
We also have shown that
TNF induces tyrosine phosphorylation and internalization of the overexpressed EGFR in NIH3T3 cells and the endogenously expressed
EGFR in A431 cells and that the transactivation by TNF is suppressed by N-acetyl-l-cysteine or overexpression of an endogenous reducing molecule, thioredoxin, but not by phosphatidylinositol 3-kinase inhibitors and protein kinase C inhibitor ... Taken together, this evidence strongly suggests that
EGFR transactivation by
TNF , which is regulated in a redox dependent manner, is playing a pivotal role in TNF induced NF-kappa B activation
Nishi et al., Int J Mol Med 2003
(Breast Neoplasms) :
Also,
TNF-alpha did not
induce EGFR expression at the protein level
Argast et al., J Biol Chem 2004
:
TNF induced release of TGFalpha and activation of
EGFR signaling were inhibited by TNFalpha protease inhibitor-1, an agent that interferes with TNFalpha converting enzyme activity
Pastore et al., J Immunol 2005
(Dermatitis, Contact...) :
We have recently observed that
epidermal growth factor receptor (EGFR) signaling
affects TNF-alpha-driven chemokine expression in epidermal keratinocytes, and its functional impairment increases the levels of crucial chemoattractants such as CCL2/MCP-1, CCL5/RANTES, and CXCL10/IFN-gamma-inducible protein-10
Ueno et al., Br J Cancer 2005
(Carcinoma, Hepatocellular...) :
Furthermore, the TNF-alpha induced responses except for NF-kappaB activation were blocked by metalloprotease inhibitors, suggesting that gefitinib inhibited the transactivation of
EGFR induced by
TNF-alpha
Chokki et al., Life Sci 2006
:
In addition,
TNF-alpha stimulated tyrosine phosphorylation of the
EGFR within 5 min after stimulation
Matsuo et al., Cancer Sci 2006
(Carcinoma, Hepatocellular...) :
We have shown that the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib ( ` Iressa ', ZD1839 ) inhibits the development of intrahepatic metastases of hepatocellular carcinoma CBO140C12, and
EGFR transactivation by
tumor necrosis factor-alpha is a possible target of gefitinib
Demirjian et al., Biochim Biophys Acta 2006
(MAP Kinase Signaling System) :
On the other hand, the PI3-K inhibitor, LY294002, and
epidermal growth factor receptor (EGFR)-specific inhibitor, AG1478, did not
suppress the release of
TNF-alpha
Finzi et al., Am J Pathol 2006
(Cholelithiasis...) :
In primary cultures of human gallbladder epithelial cells,
TNF-alpha induced
EGF-R overexpression
Cheon et al., Exp Mol Med 2007
(MAP Kinase Signaling System) :
Genistein, a protein tyrosine kinase ( PTK ) inhibitor, and PD153035, an EGFR inhibitor, also blocked the increase of TNF-alpha expression by TCDD, indicating the
role of
EGFR in TCDD induced
TNF-alpha expression ... These results indicate that
TNF-alpha production by TCDD in differentiated THP-1 macrophages is AhR dependent and
involves activation of
EGFR and ERK, but not c-Src, JNK, nor p38 MAPK
Ziv et al., J Cell Biochem 2008
(Inflammation...) :
Pretreatment with calcitriol, enhanced
TNF induced
EGFR-Src dependent ERK activation and tyrosine phosphorylation of the EGFR, but abolished the EGFR-Src independent ERK activation
McElroy et al., Am J Physiol Gastrointest Liver Physiol 2008
:
TNF attenuated EGF stimulated
EGFR phosphorylation in wild-type and TNFR2 ( -/- ), but not TNFR1 ( -/- ), mouse colon epithelial ( MCE ) cells ... Reexpression of wild-type TNFR1 in TNFR1 ( -/- ) MCE cells rescued
TNF induced
EGFR inhibition, but expression of TNFR1 deletion mutant constructs lacking the death domain ( DD ) of TNFR1 did not, implicating this domain in EGFR downregulation
Yamaoka et al., Proc Natl Acad Sci U S A 2008
:
This study was undertaken to determine the
effects of
TNF on
EGFR and ErbB2 activation and intestinal epithelial cell survival ...
TNF stimulated EGFR phosphorylation in young adult mouse colon epithelial cells, and loss of
EGFR expression or inhibition of kinase activity
increased TNF induced apoptosis, which was prevented in WT but not by kinase-inactive EGFR expression
Smith et al., J Periodontal Res 2009
:
Tumor necrosis factor-alpha induced
EGFR transactivation and stimulated the expression of the mRNA for the EGFR ligands heparin binding-epidermal growth factor ( HB-EGF ) and transforming growth factor-alpha ( TGF-alpha )
Guazzoni et al., Cancer Lett 1991
:
The
effects of
tumor necrosis factor (TNF) on
epidermal growth factor (EGF) receptor tyrosine phosphorylation were investigated in Swiss 3T3 cells, which are sensitive to TNF action
Lee et al., J Cell Physiol 2010
(MAP Kinase Signaling System) :
On the other hand,
TNF-alpha stimulated the phosphorylation of c-Src,
EGFR , Akt, JNK1/2, and c-Jun, which were inhibited by pretreatment with Gö6983
Hobbs et al., Am J Physiol Gastrointest Liver Physiol 2011
:
We hypothesized that COX-2 induction and cell survival signaling downstream of
TNF are
mediated by
EGFR transactivation
Zhao et al., J Lipid Res 2012
:
Further studies showed that
TNF-a decreased expression of the antiapoptotic proteins Bcl-2 and Bcl-xL, decreased I?Ba and PPAR?, and also
inhibited PI3K dependent Akt and
EGFR signaling
Yoo et al., Am J Physiol Gastrointest Liver Physiol 2012
:
TNF-a also
increased EGFR expression and signaling in primary myofibroblasts isolated from human colon tissue ...
TNF-a induced upregulation of
EGFR may be a plausible mechanism to explain the exaggerated cellular responsiveness that characterizes inflammatory bowel disease and that may contribute to a microenvironment that predisposes to colitis associated cancer through enhanced COX-2 expression
Berasain et al., Dig Dis 2012
(Carcinoma, Hepatocellular...) :
TNF-a triggered AR shedding and
EGFR transactivation in HCC cells ... AR release and
EGFR transactivation by
TNF-a constitutes a novel link between inflammatory signals and pro-tumorigenic mechanisms in liver cells
Takada et al., Keio J Med 2012
(Disease Models, Animal...) :
Here, we compared and monitored the
effects of
EGFR inhibitors gefitinib, erlotinib and AG1517 ( PD153035 ) on the mRNA expression levels of Fosl1,
Tnf and Ccl2
Yang et al., Biochem Pharmacol 2013
:
TNF-a stimulated c-Src, PDGFR, and
EGFR phosphorylation, which were reduced by PP1
Waheed et al., Mol Biol Cell 2013
:
In this study we explore the mechanisms underlying
TNF-a induced
EGFR activation
Bird et al., J Immunol 1989
:
The
effect of IL-1 and
TNF on
EGF-R was compared with that of the tumor-promotor PMA which is known to `` transmodulate '' EGF-R affinity by activating protein kinase C which then phosphorylates EGF-R
Schmiegel et al., Proc Natl Acad Sci U S A 1993
(Pancreatic Neoplasms...) :
Induction of
EGFR mRNA expression by
TNF-alpha was abrogated by cycloheximide but occurred independently of TNF-alpha induced production of TGF-alpha protein ... By contrast, staurosporine, an inhibitor of protein kinase C, partially inhibited, and 4-bromophenacyl bromide, a phospholipase inhibitor, completely inhibited
TNF-alpha dependent
EGFR mRNA expression ... The phospholipase C-specific inhibitor tricyclodecan-9-yl xanthogenate did not alter
TNF-alpha dependent
EGFR mRNA expression, suggesting that phospholipase A2 is involved in the modulation of EGFR expression by TNF-alpha
Kaiser et al., Gastroenterology 1997
:
TNF-alpha inhibited the mitogenic effect of growth factors and
epidermal growth factor receptor tyrosine phosphorylation
Perez et al., J Interferon Cytokine Res 1996
:
Activation of
epidermal growth factor receptor tyrosine phosphorylation by
tumor necrosis factor correlates with loss of cytotoxic activity
Miller et al., Mol Cell Biol 1998
:
Interaction of
tumor necrosis factor receptor associated factor signaling proteins with the latent membrane protein 1 PXQXT motif is
essential for induction of
epidermal growth factor receptor expression