J Biol Chem 2013,
PMID: 23319592
Connolly, Dympna J; O'Neill, Luke A J; McGettrick, Anne F
The proinflammatory danger signal IL-33, which is released from damaged or dying cells, achieves its effects via the IL-1R family member ST2L. The detection of IL-33 by ST2L initiates downstream signaling pathways that result in the activation of MAPKs and NF-κB. Here, we show that TMED1 associates with ST2L. Using a series of mutation and deletion constructs, we demonstrate that this interaction is mediated by the GOLD domain of TMED1 and the TIR domain of ST2L. Our findings also demonstrate that TMED1 is required for optimal IL-33-induced IL-8 and IL-6 production. This discovery provides additional support to the concept that the TMED family members are important players in innate immune signaling.
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Text Mining Data
IL-6 → IL-33: "
Our findings also demonstrate that TMED1 is required for optimal
IL-33 induced IL-8 and
IL-6 production
"
IL-6 → TMED1: "
Our findings also demonstrate that TMED1 is required for optimal IL-33 induced IL-8 and IL-6 production
"
IL-8 → IL-33: "
Our findings also demonstrate that TMED1 is required for optimal IL-33 induced IL-8 and IL-6 production
"
IL-8 → TMED1: "
Our findings also demonstrate that TMED1 is required for optimal IL-33 induced IL-8 and IL-6 production
"
Manually curated Databases
No curated data.