Gene interactions and pathways from curated databases and text-mining
Science 2007, PMID: 17289999

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis, Simon N; Fletcher, Jamie I; Kaufmann, Thomas; van Delft, Mark F; Chen, Lin; Czabotar, Peter E; Ierino, Helen; Lee, Erinna F; Fairlie, W Douglas; Bouillet, Philippe; Strasser, Andreas; Kluck, Ruth M; Adams, Jerry M; Huang, David C S

A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential cell-death mediators Bax and Bak, or whether they can act indirectly, by engaging their pro-survival Bcl-2-like relatives. Contrary to the direct-activation model, we show that Bax and Bak can mediate apoptosis without discernable association with the putative BH3-only activators (Bim, Bid, and Puma), even in cells with no Bim or Bid and reduced Puma. Our results indicate that BH3-only proteins induce apoptosis at least primarily by engaging the multiple pro-survival relatives guarding Bax and Bak.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Intact Interaction: BCL2 — BCL2L11 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: BCL2 — BBC3 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of BAX-BCL2L11 (physical association, surface plasmon resonance)
  • IRef Intact Interaction: Complex of BID-BID-BAX (physical association, surface plasmon resonance)
  • IRef Intact Interaction: Complex of BCL2L1-BCL2-BCL2L2-BCL2L2-PABPN1-BAX-BID (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of BAX-BAX-BID-BID (physical association, surface plasmon resonance)
  • IRef Intact Interaction: Complex of BID-BAX-BID-BCL2-BAX-BAX-BCL2-BCL2-BID (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of BID-BAX-BID-BAX (physical association, surface plasmon resonance)
  • IRef Intact Interaction: Complex of BAX-BCL2L2-BCL2L2-PABPN1-BAX-BID-BID-BCL2L2-BCL2L2-PABPN1 (physical association, surface plasmon resonance)
  • IRef Intact Interaction: Complex of BAK1-BAX-BAX (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of BCL2L11-BAX (physical association, surface plasmon resonance)
  • IRef Intact Interaction: Complex of BAX-BAK1-BAX-BCL2 (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of BAX-BID-BCL2L1-BCL2L1-BAX-BID (physical association, surface plasmon resonance)
  • IRef Intact Interaction: Complex of BCL2L1-BAX-BCL2-BCL2L11-BCL2L2-BCL2L2-PABPN1 (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: BAX — BCL2L11 (direct interaction, surface plasmon resonance)
  • IRef Intact Interaction: BMF — BCL2 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: BAX — BID (direct interaction, surface plasmon resonance)
  • IRef Intact Interaction: BAX — BCL2L1 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: BAX — BCL2 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: BID — BCL2 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: BAX — BCL2L2, BCL2L2-PABPN1 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: BIK — BCL2 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of BCL2-BCL2L11-BAX (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of BCL2L11-BCL2-BAX (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of BCL2L11-BCL2-BAX (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of BAX-BCL2L11-BCL2 (association, anti tag coimmunoprecipitation)
In total, 25 gene pairs are associated to this article in curated databases