FEBS Lett 2006,
PMID: 17134702
Lu, Jun; Zheng, Yuan-Lin; Wu, Dong-Mei; Sun, Dong-Xu; Shan, Qun; Fan, Shao-Hua
Evidence has been gathered to suggest that trace amounts of copper induce neurotoxicity by interaction with elevated cholesterol in diet. Copper treatment alone showed no significant learning and memory impairments in behavioral tasks. However, copper-induced neurotoxicity was significantly increased in mice given elevated-cholesterol diet. Trace amounts of copper decreased the activity of SOD and increased the level of malondialdehyde (MDA) in the brain of cholesterol-fed mouse. Copper also caused an increase in amyloid precursor protein (APP) mRNA level and the activation of caspase-3 in the brain of cholesterol-fed mice. The apoptosis-induced nuclear DNA fragmentation was detected in the brain of those mice by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end-labeling staining. These findings suggest that trace amounts of copper induce neurotoxicity in cholesterol-fed mice through apoptosis caused by oxidative stress.
Diseases/Pathways annotated by Medline MESH: Learning Disorders, Memory Disorders
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Text Mining Data
amyloid precursor protein (APP) → caspase-3: "
Copper also caused an increase in
amyloid precursor protein (APP) mRNA level and the
activation of
caspase-3 in the brain of cholesterol fed mice
"
Manually curated Databases
No curated data.