Mouse Gene Pax8 (ENSMUST00000028355.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired box 8 (Pax8), mRNA. (from RefSeq NM_011040)
RefSeq Summary (NM_011040): This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Mar 2013].
Gencode Transcript: ENSMUST00000028355.10
Gencode Gene: ENSMUSG00000026976.15
Transcript (Including UTRs)
   Position: mm10 chr2:24,420,560-24,475,599 Size: 55,040 Total Exon Count: 12 Strand: -
Coding Region
   Position: mm10 chr2:24,421,548-24,475,097 Size: 53,550 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:24,420,560-24,475,599)mRNA (may differ from genome)Protein (457 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
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-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Paired box protein Pax-8;
FUNCTION: Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.
SUBUNIT: Interacts with WWTR1 (By similarity).
TISSUE SPECIFICITY: Expressed in the developing excretory system and the thyroid gland.
SIMILARITY: Contains 1 paired domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -85.60198-0.432 Picture PostScript Text
3' UTR -271.40988-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009057 - Homeodomain-like
IPR001523 - Paired_dom
IPR022130 - Pax2_C
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00292 - 'Paired box' domain
PF12403 - Paired-box protein 2 C terminal

SCOP Domains:
46689 - Homeodomain-like
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q00288
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding

Biological Process:
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0003281 ventricular septum development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006790 sulfur compound metabolic process
GO:0007275 multicellular organism development
GO:0007417 central nervous system development
GO:0009887 animal organ morphogenesis
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0030154 cell differentiation
GO:0030878 thyroid gland development
GO:0039003 pronephric field specification
GO:0042472 inner ear morphogenesis
GO:0042981 regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048793 pronephros development
GO:0071371 cellular response to gonadotropin stimulus
GO:0071599 otic vesicle development
GO:0072050 S-shaped body morphogenesis
GO:0072073 kidney epithelium development
GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072164 mesonephric tubule development
GO:0072207 metanephric epithelium development
GO:0072221 metanephric distal convoluted tubule development
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072289 metanephric nephron tubule formation
GO:0072305 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215 negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218 negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:2000594 positive regulation of metanephric DCT cell differentiation
GO:2000611 positive regulation of thyroid hormone generation
GO:2000612 regulation of thyroid-stimulating hormone secretion

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex

-  Descriptions from all associated GenBank mRNAs
  AK052610 - Mus musculus 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630004L01 product:PAIRED BOX GENE 8 homolog [Mus musculus], full insert sequence.
BC020526 - Mus musculus paired box gene 8, mRNA (cDNA clone MGC:18390 IMAGE:4239835), complete cds.
X57487 - M.musculus mRNA Pax8.
AK050717 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030009M16 product:PAIRED BOX GENE 8 homolog [Mus musculus], full insert sequence.
AK032920 - Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720473A10 product:paired box gene 8, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu05200 - Pathways in cancer
mmu05216 - Thyroid cancer

-  Other Names for This Gene
  Alternate Gene Symbols: NM_011040, P97342, Pax-8, PAX8_MOUSE, Q00288, Q6GU20, uc008ipb.1, uc008ipb.2, uc008ipb.3
UCSC ID: uc008ipb.3
RefSeq Accession: NM_011040
Protein: Q00288 (aka PAX8_MOUSE)
CCDS: CCDS15738.1

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