Mouse Gene Pax8 (ENSMUST00000028355.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus paired box 8 (Pax8), mRNA. (from RefSeq NM_011040) RefSeq Summary (NM_011040): This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Mar 2013]. Gencode Transcript: ENSMUST00000028355.10 Gencode Gene: ENSMUSG00000026976.15 Transcript (Including UTRs) Position: mm10 chr2:24,420,560-24,475,599 Size: 55,040 Total Exon Count: 12 Strand: - Coding Region Position: mm10 chr2:24,421,548-24,475,097 Size: 53,550 Coding Exon Count: 11
ID:PAX8_MOUSE DESCRIPTION: RecName: Full=Paired box protein Pax-8; FUNCTION: Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development. SUBUNIT: Interacts with WWTR1 (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in the developing excretory system and the thyroid gland. SIMILARITY: Contains 1 paired domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q00288
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding
Biological Process: GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001822 kidney development GO:0001823 mesonephros development GO:0003281 ventricular septum development GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006790 sulfur compound metabolic process GO:0007275 multicellular organism development GO:0007417 central nervous system development GO:0009887 animal organ morphogenesis GO:0010667 negative regulation of cardiac muscle cell apoptotic process GO:0030154 cell differentiation GO:0030878 thyroid gland development GO:0039003 pronephric field specification GO:0042472 inner ear morphogenesis GO:0042981 regulation of apoptotic process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048793 pronephros development GO:0071371 cellular response to gonadotropin stimulus GO:0071599 otic vesicle development GO:0072050 S-shaped body morphogenesis GO:0072073 kidney epithelium development GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072164 mesonephric tubule development GO:0072207 metanephric epithelium development GO:0072221 metanephric distal convoluted tubule development GO:0072278 metanephric comma-shaped body morphogenesis GO:0072284 metanephric S-shaped body morphogenesis GO:0072289 metanephric nephron tubule formation GO:0072305 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis GO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900215 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900218 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:2000594 positive regulation of metanephric DCT cell differentiation GO:2000611 positive regulation of thyroid hormone generation GO:2000612 regulation of thyroid-stimulating hormone secretion