ID:PAX1_MOUSE DESCRIPTION: RecName: Full=Paired box protein Pax-1; FUNCTION: This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column. SUBCELLULAR LOCATION: Nucleus. DISEASE: Note=Undulated (un) homozygous mice exhibits vertebral malformations along the entire rostro-caudal axis. This is due to a single mutation in the paired box region. SIMILARITY: Contains 1 paired domain. SEQUENCE CAUTION: Sequence=AAA37793.1; Type=Erroneous gene model prediction; Sequence=AAA39888.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09084
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding
Biological Process: GO:0001501 skeletal system development GO:0001756 somitogenesis GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007389 pattern specification process GO:0008283 cell proliferation GO:0009887 animal organ morphogenesis GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043374 CD8-positive, alpha-beta T cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048538 thymus development GO:0060017 parathyroid gland development GO:0060349 bone morphogenesis GO:0061056 sclerotome development
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