ID:NACA_MOUSE DESCRIPTION: RecName: Full=Nascent polypeptide-associated complex subunit alpha; AltName: Full=Alpha-NAC; AltName: Full=Alpha-NAC/1.9.2; FUNCTION: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). Isoform 1 and isoform 2 appear to bind DNA and play roles in transcription. Isoform 1 may function as a specific coactivator for JUN, acting to stabilize the interaction of JUN homodimers with promoter elements. SUBUNIT: Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains (By similarity). Interacts with TBP and JUN. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Isoform 1 appears to be ubiquitously expressed. DEVELOPMENTAL STAGE: Expressed concomitant with the onset of mineralization in ossification centers of developing bone. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation. SIMILARITY: Belongs to the NAC-alpha family. SIMILARITY: Contains 1 NAC-A/B (NAC-alpha/beta) domain. SIMILARITY: Contains 1 UBA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q60817
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003713 transcription coactivator activity GO:0017025 TBP-class protein binding
Biological Process: GO:0003231 cardiac ventricle development GO:0006351 transcription, DNA-templated GO:0010664 negative regulation of striated muscle cell apoptotic process GO:0015031 protein transport GO:0043403 skeletal muscle tissue regeneration GO:0048633 positive regulation of skeletal muscle tissue growth GO:0048742 regulation of skeletal muscle fiber development GO:0051451 myoblast migration GO:0061384 heart trabecula morphogenesis GO:1901227 negative regulation of transcription from RNA polymerase II promoter involved in heart development GO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in heart development GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis
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