Mouse Gene Naca (ENSMUST00000073868.9) from GENCODE VM27
  Description: Mus musculus nascent polypeptide-associated complex alpha polypeptide (Naca), transcript variant 2, mRNA. (from RefSeq NM_013608)
Gencode Transcript: ENSMUST00000073868.9
Gencode Gene: ENSMUSG00000061315.15
Transcript (Including UTRs)
   Position: mm39 chr10:127,871,444-127,884,502 Size: 13,059 Total Exon Count: 8 Strand: +
Coding Region
   Position: mm39 chr10:127,872,360-127,884,376 Size: 12,017 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2021-08-05 19:35:23

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:127,871,444-127,884,502)mRNA (may differ from genome)Protein (215 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: NACA_MOUSE
DESCRIPTION: RecName: Full=Nascent polypeptide-associated complex subunit alpha; AltName: Full=Alpha-NAC; AltName: Full=Alpha-NAC/1.9.2;
FUNCTION: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). Isoform 1 and isoform 2 appear to bind DNA and play roles in transcription. Isoform 1 may function as a specific coactivator for JUN, acting to stabilize the interaction of JUN homodimers with promoter elements.
SUBUNIT: Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains (By similarity). Interacts with TBP and JUN.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Isoform 1 appears to be ubiquitously expressed.
DEVELOPMENTAL STAGE: Expressed concomitant with the onset of mineralization in ossification centers of developing bone.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation.
SIMILARITY: Belongs to the NAC-alpha family.
SIMILARITY: Contains 1 NAC-A/B (NAC-alpha/beta) domain.
SIMILARITY: Contains 1 UBA domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.30111-0.309 Picture PostScript Text
3' UTR -26.40126-0.210 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002715 - Nas_poly-pep-assoc_cplx
IPR016641 - Nas_poly-pep-assoc_cplx_asu

Pfam Domains:
PF01849 - NAC domain

ModBase Predicted Comparative 3D Structure on Q60817
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
 RGDEnsemblEnsembl SGD
Protein SequenceProtein SequenceProtein SequenceProtein Sequence Protein Sequence
AlignmentAlignmentAlignmentAlignment Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0017025 TBP-class protein binding

Biological Process:
GO:0003231 cardiac ventricle development
GO:0006351 transcription, DNA-templated
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0015031 protein transport
GO:0043403 skeletal muscle tissue regeneration
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0048742 regulation of skeletal muscle fiber development
GO:0051451 myoblast migration
GO:0061384 heart trabecula morphogenesis
GO:1901227 negative regulation of transcription from RNA polymerase II promoter involved in heart development
GO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in heart development
GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005854 nascent polypeptide-associated complex


-  Descriptions from all associated GenBank mRNAs
  AK169432 - Mus musculus 17 days embryo whole body cDNA, RIKEN full-length enriched library, clone:K630044L20 product:nascent polypeptide-associated complex alpha polypeptide, full insert sequence.
AK146197 - Mus musculus TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730032G02 product:nascent polypeptide-associated complex alpha polypeptide, full insert sequence.
AL355707 - Mus musculus EST from clone 1969678, 5' end.
AK168023 - Mus musculus TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730047O06 product:nascent polypeptide-associated complex alpha polypeptide, full insert sequence.
U48364 - Mus musculus muscle-specific transcriptional activator alpha-NAC gp220 (Naca) mRNA, complete cds.
AK146149 - Mus musculus CRL-1722 L5178Y-R cDNA, RIKEN full-length enriched library, clone:I730023C04 product:nascent polypeptide-associated complex alpha polypeptide, full insert sequence.
AK168169 - Mus musculus CRL-1722 L5178Y-R cDNA, RIKEN full-length enriched library, clone:I730062H19 product:nascent polypeptide-associated complex alpha polypeptide, full insert sequence.
AK169435 - Mus musculus adult male heart cDNA, RIKEN full-length enriched library, clone:K630108L16 product:nascent polypeptide-associated complex alpha polypeptide, full insert sequence.
AK151928 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830043F22 product:nascent polypeptide-associated complex alpha polypeptide, full insert sequence.
AK161678 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730512N08 product:nascent polypeptide-associated complex alpha polypeptide, full insert sequence.
BC029830 - Mus musculus nascent polypeptide-associated complex alpha polypeptide, mRNA (cDNA clone IMAGE:3992262), complete cds.
BC083340 - Mus musculus nascent polypeptide-associated complex alpha polypeptide, mRNA (cDNA clone MGC:102085 IMAGE:5700166), complete cds.
AK168607 - Mus musculus 16 days embryo kidney cDNA, RIKEN full-length enriched library, clone:I920038A19 product:nascent polypeptide-associated complex alpha polypeptide, full insert sequence.
U22151 - Mus musculus translational regulatory factor alpha NAC/1.9.2. protein mRNA, complete cds.
BC099375 - Mus musculus nascent polypeptide-associated complex alpha polypeptide, mRNA (cDNA clone MGC:117501 IMAGE:30525972), complete cds.
LF271646 - JP 2014500723-A/79149: Polycomb-Associated Non-Coding RNAs.
MA507223 - JP 2018138019-A/79149: Polycomb-Associated Non-Coding RNAs.
LF271648 - JP 2014500723-A/79151: Polycomb-Associated Non-Coding RNAs.
MA507225 - JP 2018138019-A/79151: Polycomb-Associated Non-Coding RNAs.
LF271649 - JP 2014500723-A/79152: Polycomb-Associated Non-Coding RNAs.
MA507226 - JP 2018138019-A/79152: Polycomb-Associated Non-Coding RNAs.
AK217128 - Mus musculus cDNA, clone:Y2G0140L24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000046194, based on BLAT search.

-  Other Names for This Gene
  Alternate Gene Symbols: ENSMUST00000073868.1, ENSMUST00000073868.2, ENSMUST00000073868.3, ENSMUST00000073868.4, ENSMUST00000073868.5, ENSMUST00000073868.6, ENSMUST00000073868.7, ENSMUST00000073868.8, NACA_MOUSE, NM_013608, Q3THR6, Q4FZL8, Q60817, uc007hlb.1, uc007hlb.2, uc007hlb.3, uc007hlb.4
UCSC ID: ENSMUST00000073868.9
RefSeq Accession: NM_013608
Protein: Q60817 (aka NACA_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.