Human Gene PAX1 (ENST00000613128.5) from GENCODE V43
Description: Homo sapiens paired box 1 (PAX1), transcript variant 2, mRNA. (from RefSeq NM_001257096) RefSeq Summary (NM_001257096): This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012]. Gencode Transcript: ENST00000613128.5 Gencode Gene: ENSG00000125813.15 Transcript (Including UTRs) Position: hg38 chr20:21,705,664-21,718,481 Size: 12,818 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr20:21,705,713-21,714,562 Size: 8,850 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.