Human Gene SLC25A21 (ENST00000331299.6) from GENCODE V44
  Description: Homo sapiens solute carrier family 25 member 21 (SLC25A21), transcript variant 1, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_030631)
RefSeq Summary (NM_030631): SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004].
Gencode Transcript: ENST00000331299.6
Gencode Gene: ENSG00000183032.12
Transcript (Including UTRs)
   Position: hg38 chr14:36,677,921-37,172,606 Size: 494,686 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr14:36,680,658-37,172,350 Size: 491,693 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 09:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:36,677,921-37,172,606)mRNA (may differ from genome)Protein (299 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Mitochondrial 2-oxodicarboxylate carrier; AltName: Full=Solute carrier family 25 member 21;
FUNCTION: Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.08 RPKM in Testis
Total median expression: 12.41 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.60256-0.393 Picture PostScript Text
3' UTR -537.302737-0.196 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

ModBase Predicted Comparative 3D Structure on Q9BQT8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005310 dicarboxylic acid transmembrane transporter activity
GO:0015139 alpha-ketoglutarate transmembrane transporter activity

Biological Process:
GO:0006554 lysine catabolic process
GO:0006835 dicarboxylic acid transport
GO:0006839 mitochondrial transport
GO:0015742 alpha-ketoglutarate transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK289575 - Homo sapiens cDNA FLJ75243 complete cds, highly similar to Homo sapiens solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 (SLC25A21), mRNA.
AJ278148 - Homo sapiens partial mRNA for oxodicarboxylate carrier (ODC gene).
BC113365 - Homo sapiens solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21, mRNA (cDNA clone MGC:141925 IMAGE:8322417), complete cds.
BC101521 - Homo sapiens solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21, mRNA (cDNA clone MGC:126570 IMAGE:8069027), complete cds.
HQ258164 - Synthetic construct Homo sapiens clone IMAGE:100072473 solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 (SLC25A21) gene, encodes complete protein.
KJ895100 - Synthetic construct Homo sapiens clone ccsbBroadEn_04494 SLC25A21 gene, encodes complete protein.
JD206682 - Sequence 187706 from Patent EP1572962.
JD380298 - Sequence 361322 from Patent EP1572962.
JD462150 - Sequence 443174 from Patent EP1572962.
JD522074 - Sequence 503098 from Patent EP1572962.
JD488485 - Sequence 469509 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BQT8 (Reactome details) participates in the following event(s):

R-HSA-372480 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]
R-HSA-71064 Lysine catabolism
R-HSA-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000331299.1, ENST00000331299.2, ENST00000331299.3, ENST00000331299.4, ENST00000331299.5, NM_030631, ODC, ODC_HUMAN, Q3MJ99, Q9BQT8, uc001wtz.1, uc001wtz.2, uc001wtz.3, uc001wtz.4
UCSC ID: ENST00000331299.6
RefSeq Accession: NM_030631
Protein: Q9BQT8 (aka ODC_HUMAN)
CCDS: CCDS9663.1, CCDS55913.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.