ID:MFRN2_MOUSE DESCRIPTION: RecName: Full=Mitoferrin-2; AltName: Full=Mitochondrial RNA-splicing protein 3/4 homolog; Short=MRS3/4; AltName: Full=Mitochondrial iron transporter 2; AltName: Full=Solute carrier family 25 member 28; FUNCTION: Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (Probable). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion. TISSUE SPECIFICITY: Ubiquitously expressed at low level. Expressed at higher level in heart, liver, kidney and testis. Expression does not vary during erythroid maturation. SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8R0Z5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005381 iron ion transmembrane transporter activity GO:0015093 ferrous iron transmembrane transporter activity
Biological Process: GO:0006811 ion transport GO:0006839 mitochondrial transport GO:0048250 mitochondrial iron ion transport GO:0055072 iron ion homeostasis GO:1903874 ferrous iron transmembrane transport
US Server
