Mouse Gene Slc25a2 (ENSMUST00000058635.3) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2 (Slc25a2), mRNA. (from RefSeq NM_001159275)
Gencode Transcript: ENSMUST00000058635.3
Gencode Gene: ENSMUSG00000050304.3
Transcript (Including UTRs)
   Position: mm10 chr18:37,637,377-37,638,745 Size: 1,369 Total Exon Count: 1 Strand: -
Coding Region
   Position: mm10 chr18:37,637,677-37,638,474 Size: 798 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:37,637,377-37,638,745)mRNA (may differ from genome)Protein (265 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q99ML6_MOUSE
DESCRIPTION: SubName: Full=MCG1033320; SubName: Full=Mutant ornithine transporter 2; SubName: Full=Protein Slc25a2; SubName: Full=Solute carrier family 25 (Mitochondrial carrier, ornithine transporter) member 2;
SIMILARITY: Belongs to the mitochondrial carrier family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -101.00271-0.373 Picture PostScript Text
3' UTR -73.60300-0.245 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q99ML6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000064 L-ornithine transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:1903352 L-ornithine transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF332006 - Mus musculus mutant ornithine transporter 2 (Ornt2) mRNA, complete cds.
AK077159 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4933415J19 product:ornithine transporter 2, full insert sequence.
AY583456 - Mus musculus mitochondrial ornithine transporter (Ornt2) pseudogene mRNA, complete sequence; nuclear gene for mitochondrial protein.
BC114348 - Mus musculus solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2, mRNA (cDNA clone MGC:130114 IMAGE:40051484), complete cds.
BC125010 - Mus musculus solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2, mRNA (cDNA clone MGC:130113 IMAGE:40051483), complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q99ML6 (Reactome details) participates in the following event(s):

R-MMU-70634 ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
R-MMU-70635 Urea cycle
R-MMU-351202 Metabolism of polyamines
R-MMU-71291 Metabolism of nitrogenous molecules
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_1033320, NM_001159275, Ornt2, Q99ML6, Q99ML6_MOUSE, uc008eqh.1, uc008eqh.2, uc008eqh.3
UCSC ID: uc008eqh.3
RefSeq Accession: NM_001159275
Protein: Q99ML6 CCDS: CCDS50258.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.