Mouse Gene Pax1 (ENSMUST00000109968.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired box 1 (Pax1), mRNA. (from RefSeq NM_008780)
Gencode Transcript: ENSMUST00000109968.2
Gencode Gene: ENSMUSG00000037034.16
Transcript (Including UTRs)
   Position: mm10 chr2:147,364,994-147,375,053 Size: 10,060 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr2:147,365,048-147,373,805 Size: 8,758 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Paired box protein Pax-1;
FUNCTION: This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column.
DISEASE: Note=Undulated (un) homozygous mice exhibits vertebral malformations along the entire rostro-caudal axis. This is due to a single mutation in the paired box region.
SIMILARITY: Contains 1 paired domain.
SEQUENCE CAUTION: Sequence=AAA37793.1; Type=Erroneous gene model prediction; Sequence=AAA39888.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

+  Comparative Toxicogenomics Database (CTD)
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.4054-0.100 Picture PostScript Text
3' UTR -354.901248-0.284 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009057 - Homeodomain-like
IPR001523 - Paired_dom
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00292 - 'Paired box' domain
PF13384 - Homeodomain-like domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on P09084
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

+  Gene Ontology (GO) Annotations with Structured Vocabulary
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-  Descriptions from all associated GenBank mRNAs
  AB080657 - Mus musculus Pax1 mRNA, partial cds, clone:5832438N23.
AB080656 - Mus musculus Pax1 mRNA, partial cds, clone:A430036B21.
AK134066 - Mus musculus adult male thymus cDNA, RIKEN full-length enriched library, clone:5830427P13 product:paired box gene 1, full insert sequence.
M69222 - Mouse Pax-1 protein (Pax-1) mRNA, complete cds.
BC140989 - Mus musculus paired box gene 1, mRNA (cDNA clone MGC:175950 IMAGE:9055601), complete cds.
AK041531 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630019K16 product:paired box gene 1, full insert sequence.

+  Other Names for This Gene
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-  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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