Mouse Gene Pax8 (ENSMUST00000028355.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus paired box 8 (Pax8), mRNA. (from RefSeq NM_011040) RefSeq Summary (NM_011040): This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Mar 2013]. Gencode Transcript: ENSMUST00000028355.10 Gencode Gene: ENSMUSG00000026976.15 Transcript (Including UTRs) Position: mm10 chr2:24,420,560-24,475,599 Size: 55,040 Total Exon Count: 12 Strand: - Coding Region Position: mm10 chr2:24,421,548-24,475,097 Size: 53,550 Coding Exon Count: 11
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Comments and Description Text from UniProtKB
ID:PAX8_MOUSE DESCRIPTION: RecName: Full=Paired box protein Pax-8; FUNCTION: Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development. SUBUNIT: Interacts with WWTR1 (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in the developing excretory system and the thyroid gland. SIMILARITY: Contains 1 paired domain.
Comparative Toxicogenomics Database (CTD)
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q00288
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
