Mouse Gene Pax8 (ENSMUST00000028355.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired box 8 (Pax8), mRNA. (from RefSeq NM_011040)
RefSeq Summary (NM_011040): This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Mar 2013].
Gencode Transcript: ENSMUST00000028355.10
Gencode Gene: ENSMUSG00000026976.15
Transcript (Including UTRs)
   Position: mm10 chr2:24,420,560-24,475,599 Size: 55,040 Total Exon Count: 12 Strand: -
Coding Region
   Position: mm10 chr2:24,421,548-24,475,097 Size: 53,550 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-20

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: PAX8_MOUSE
DESCRIPTION: RecName: Full=Paired box protein Pax-8;
FUNCTION: Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.
SUBUNIT: Interacts with WWTR1 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in the developing excretory system and the thyroid gland.
SIMILARITY: Contains 1 paired domain.

+  Comparative Toxicogenomics Database (CTD)
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -85.60198-0.432 Picture PostScript Text
3' UTR -271.40988-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009057 - Homeodomain-like
IPR001523 - Paired_dom
IPR022130 - Pax2_C
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00292 - 'Paired box' domain
PF12403 - Paired-box protein 2 C terminal

SCOP Domains:
46689 - Homeodomain-like
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q00288
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

+  Gene Ontology (GO) Annotations with Structured Vocabulary
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-  Descriptions from all associated GenBank mRNAs
  AK052610 - Mus musculus 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630004L01 product:PAIRED BOX GENE 8 homolog [Mus musculus], full insert sequence.
BC020526 - Mus musculus paired box gene 8, mRNA (cDNA clone MGC:18390 IMAGE:4239835), complete cds.
X57487 - M.musculus mRNA Pax8.
AK050717 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030009M16 product:PAIRED BOX GENE 8 homolog [Mus musculus], full insert sequence.
AK032920 - Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720473A10 product:paired box gene 8, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu05200 - Pathways in cancer
mmu05216 - Thyroid cancer

+  Other Names for This Gene
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-  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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