ID:UCP3_MOUSE DESCRIPTION: RecName: Full=Mitochondrial uncoupling protein 3; Short=UCP 3; AltName: Full=Solute carrier family 25 member 9; FUNCTION: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P56501
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P56501 (Reactome details) participates in the following event(s):
R-MMU-166220 FA anion diffuses laterally to UCP R-MMU-166387 The FA anion diffuses away laterally from UCP R-MMU-166214 FA anion flip-flops to the opposite surface R-MMU-170026 Protons are translocated from the intermembrane space to the matrix R-MMU-167826 The fatty acid cycling model R-MMU-166187 Mitochondrial Uncoupling Proteins R-MMU-167827 The proton buffering model R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport R-MMU-1430728 Metabolism
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