ID:MCAT_MOUSE DESCRIPTION: RecName: Full=Mitochondrial carnitine/acylcarnitine carrier protein; AltName: Full=Carnitine/acylcarnitine translocase; Short=CAC; Short=mCAC; AltName: Full=Solute carrier family 25 member 20; FUNCTION: Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00153 - Mitochondrial carrier protein
ModBase Predicted Comparative 3D Structure on Q9Z2Z6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006839 mitochondrial transport GO:0015879 carnitine transport GO:1902603 carnitine transmembrane transport GO:1902616 acyl carnitine transmembrane transport
AK161086 - Mus musculus 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732409K14 product:solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20, full insert sequence. AK075624 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110007P09 product:solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20, full insert sequence. BC029733 - Mus musculus solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20, mRNA (cDNA clone MGC:25786 IMAGE:4019406), complete cds. AK152436 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830072E12 product:solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20, full insert sequence. AB017112 - Mus musculus mCAC gene, complete cds. BC052871 - Mus musculus solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20, mRNA (cDNA clone MGC:60486 IMAGE:30032324), complete cds. AK211911 - Mus musculus cDNA, clone:Y2G0123E07, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000035222, based on BLAT search. AK183069 - Mus musculus cDNA, clone:Y0G0124K02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000035222, based on BLAT search. AK177588 - Mus musculus cDNA, clone:Y0G0103E22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000035222, based on BLAT search. AK215475 - Mus musculus cDNA, clone:Y2G0135C22, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000035222, based on BLAT search.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Z2Z6 (Reactome details) participates in the following event(s):
R-MMU-200424 Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane R-MMU-200425 Import of palmitoyl-CoA into the mitochondrial matrix R-MMU-8978868 Fatty acid metabolism R-MMU-556833 Metabolism of lipids R-MMU-1430728 Metabolism