ID:TPC_MOUSE DESCRIPTION: RecName: Full=Mitochondrial thiamine pyrophosphate carrier; AltName: Full=Solute carrier family 25 member 19; FUNCTION: Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). MISCELLANEOUS: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity). SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9DAM5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006839 mitochondrial transport GO:0030974 thiamine pyrophosphate transport GO:0055085 transmembrane transport GO:0071934 thiamine transmembrane transport
Cellular Component: GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0031305 integral component of mitochondrial inner membrane
Descriptions from all associated GenBank mRNAs
AK184738 - Mus musculus cDNA, clone:Y0G0131F15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000065066, based on BLAT search. BC018167 - Mus musculus solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19, mRNA (cDNA clone MGC:25742 IMAGE:3989263), complete cds. BC046767 - Mus musculus solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19, mRNA (cDNA clone MGC:57924 IMAGE:5694117), complete cds. AK172622 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830220L17 product:solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19, full insert sequence. AK005710 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:1700007G02 product:solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19, full insert sequence. AK168145 - Mus musculus TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730060L23 product:solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19, full insert sequence. AK194051 - Mus musculus cDNA, clone:Y1G0114C16, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000021089, based on BLAT search. AK179517 - Mus musculus cDNA, clone:Y0G0110L07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000021089, based on BLAT search.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9DAM5 (Reactome details) participates in the following event(s):
R-MMU-8875838 SLC25A19 transports ThDP from cytosol to mitochondrial matrix R-MMU-196819 Vitamin B1 (thiamin) metabolism R-MMU-196849 Metabolism of water-soluble vitamins and cofactors R-MMU-196854 Metabolism of vitamins and cofactors R-MMU-1430728 Metabolism
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