Mouse Gene Slc25a32 (ENSMUST00000022908.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 25, member 32 (Slc25a32), mRNA. (from RefSeq NM_172402)
Gencode Transcript: ENSMUST00000022908.9
Gencode Gene: ENSMUSG00000022299.9
Transcript (Including UTRs)
   Position: mm10 chr15:39,091,231-39,112,716 Size: 21,486 Total Exon Count: 7 Strand: -
Coding Region
   Position: mm10 chr15:39,095,970-39,112,501 Size: 16,532 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:39,091,231-39,112,716)mRNA (may differ from genome)Protein (316 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: MFTC_MOUSE
DESCRIPTION: RecName: Full=Mitochondrial folate transporter/carrier; AltName: Full=Solute carrier family 25 member 32;
FUNCTION: Transports folate across the inner membranes of mitochondria (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.30215-0.485 Picture PostScript Text
3' UTR -1269.304739-0.268 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
63748 - Tudor/PWWP/MBT
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q8BMG8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008517 folic acid transporter activity
GO:0015230 FAD transmembrane transporter activity

Biological Process:
GO:0006544 glycine metabolic process
GO:0006839 mitochondrial transport
GO:0015884 folic acid transport
GO:0035350 FAD transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK051059 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030063E12 product:unclassifiable, full insert sequence.
LF204473 - JP 2014500723-A/11976: Polycomb-Associated Non-Coding RNAs.
LF200237 - JP 2014500723-A/7740: Polycomb-Associated Non-Coding RNAs.
LF243686 - JP 2014500723-A/51189: Polycomb-Associated Non-Coding RNAs.
LF243687 - JP 2014500723-A/51190: Polycomb-Associated Non-Coding RNAs.
AK145178 - Mus musculus mammary gland RCB-0527 Jyg-MC(B) cDNA, RIKEN full-length enriched library, clone:G930012K01 product:mitochondrial folate transporter/carrier, full insert sequence.
BC031874 - Mus musculus solute carrier family 25, member 32, mRNA (cDNA clone MGC:30372 IMAGE:5149984), complete cds.
AK011759 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610043O12 product:weakly similar to FOLATE TRANSPORTER/CARRIER [Homo sapiens], full insert sequence.
AK167501 - Mus musculus 15 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530017L05 product:mitochondrial folate transporter/carrier, full insert sequence.
AK170643 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630112E19 product:mitochondrial folate transporter/carrier, full insert sequence.
AK031187 - Mus musculus 13 days embryo forelimb cDNA, RIKEN full-length enriched library, clone:5930424M21 product:FOLATE TRANSPORTER/CARRIER homolog [Homo sapiens], full insert sequence.
AK208271 - Mus musculus cDNA, clone:Y2G0110K06, strand:unspecified.
AK219382 - Mus musculus cDNA, clone:Y2G0148E21, strand:unspecified.
AK172029 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830031L01 product:mitochondrial folate transporter/carrier, full insert sequence.
AK211917 - Mus musculus cDNA, clone:Y2G0123E13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022908, based on BLAT search.
LF243688 - JP 2014500723-A/51191: Polycomb-Associated Non-Coding RNAs.
AK172597 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830218I18 product:mitochondrial folate transporter/carrier, full insert sequence.
AK187971 - Mus musculus cDNA, clone:Y0G0143K15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022908, based on BLAT search.
MA440050 - JP 2018138019-A/11976: Polycomb-Associated Non-Coding RNAs.
MA435814 - JP 2018138019-A/7740: Polycomb-Associated Non-Coding RNAs.
MA479263 - JP 2018138019-A/51189: Polycomb-Associated Non-Coding RNAs.
MA479264 - JP 2018138019-A/51190: Polycomb-Associated Non-Coding RNAs.
MA479265 - JP 2018138019-A/51191: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8BMG8 (Reactome details) participates in the following event(s):

R-MMU-200680 Cytosolic tetrahydrofolate import across the inner mitochondrial membrane
R-MMU-200720 Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane
R-MMU-196757 Metabolism of folate and pterines
R-MMU-196849 Metabolism of water-soluble vitamins and cofactors
R-MMU-196854 Metabolism of vitamins and cofactors
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: Mftc, MFTC_MOUSE, NM_172402, Q3TCM5, Q8BMG8, uc007vob.1, uc007vob.2, uc007vob.3
UCSC ID: uc007vob.3
RefSeq Accession: NM_172402
Protein: Q8BMG8 (aka MFTC_MOUSE)
CCDS: CCDS27443.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.