Mouse Gene Duxbl3 (ENSMUST00000100804.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus double homeobox B-like 3 (Duxbl3), mRNA. (from RefSeq NM_001177539)
Gencode Transcript: ENSMUST00000100804.4
Gencode Gene: ENSMUSG00000072672.10
Transcript (Including UTRs)
   Position: mm10 chr14:26,262,258-26,269,436 Size: 7,179 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr14:26,262,767-26,268,662 Size: 5,896 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:26,262,258-26,269,436)mRNA (may differ from genome)Protein (350 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q7TNE6_MOUSE
DESCRIPTION: SubName: Full=Double homeobox B-like; SubName: Full=Double homeodomain protein; SubName: Full=Protein Duxbl; SubName: Full=Protein Gm10391; SubName: Full=Protein Gm10394;
SUBCELLULAR LOCATION: Nucleus (By similarity).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.50509-0.292 Picture PostScript Text
3' UTR -213.40774-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like
48295 - TrpR-like
46955 - Putative DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q7TNE6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0003677 DNA binding

Biological Process:
GO:0008150 biological_process
GO:0045580 regulation of T cell differentiation

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK134879 - Mus musculus adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430501O11 product:weakly similar to Homeobox-like sequence. Part of tandem repeat (Fragment) [Homo sapiens], full insert sequence.
BC055782 - Mus musculus double homeobox B-like, mRNA (cDNA clone MGC:67567 IMAGE:6403934), complete cds.
EF472598 - Mus musculus double homeodomain protein mRNA, complete cds.
AK141686 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030023E22 product:weakly similar to Putative homeobox protein (Fragment) [Macaca mulatta], full insert sequence.
EU257807 - Mus musculus double homeodomain-related protein mRNA, complete cds.
AK004227 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110051B16 product:hypothetical protein, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: Duxbl, Gm10391, Gm10394, NM_001177539, Q7TNE6, Q7TNE6_MOUSE, uc011zhr.1, uc011zhr.2
UCSC ID: uc011zhr.2
RefSeq Accession: NM_183389
Protein: Q7TNE6 CCDS: CCDS49428.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.