ID:NKX12_MOUSE DESCRIPTION: RecName: Full=NK1 transcription factor-related protein 2; AltName: Full=Homeobox protein SAX-1; AltName: Full=NKX-1.1; FUNCTION: May function in cell specification, particularly in the CNS. SUBUNIT: Interacts with HIPK1, HIPK2, and HIPK3. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expression detected in adult brain, testis and spleen. In the testis, expressed in the germ cells of the seminiferous epithelium, in elongating spermatids and in spermatozoa. Expressed throughout the brain with highest levels in regions of the cerebral cortex, hippocampus, diencephalon, pons, medulla and cerebellum. In the embryo, expressed in the developing posterior central nervous system. First seen in the ectoderm lateral to the primitive streak, later it encompasses the neural plate. Starting at day 9.5 pc, expressed in distinct areas of spinal cord, hindbrain, midbrain and forebrain. DEVELOPMENTAL STAGE: In the embryo, expressed at highest levels at day 10 with levels decreasing during further development. PTM: Phosphorylated by HIPK2 in vitro. SIMILARITY: Belongs to the NK-1 homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain. SEQUENCE CAUTION: Sequence=AAF43670.1; Type=Erroneous gene model prediction; Sequence=AAF43672.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAF43674.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P42580
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.