ID:EVX1_MOUSE DESCRIPTION: RecName: Full=Homeobox even-skipped homolog protein 1; AltName: Full=EVX-1; FUNCTION: May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Shows a graded distribution in the primitive streak and in cells lateral to it. It is not detected in cells along the A-P axis of the embryo anterior to the primitive streak, except at E7.5 when there is transient expression in the head process. The highest levels of expression are found within the proximal (posterior) portion of the primitive streak and cells near it, with expression levels decreasing more distally (anteriorly). SIMILARITY: Belongs to the even-skipped homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23683
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0009792 embryo development ending in birth or egg hatching GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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Sequence and Links to Tools and Databases 
