Mouse Gene Alx3 (ENSMUST00000014747.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus aristaless-like homeobox 3 (Alx3), mRNA. (from RefSeq NM_007441)
RefSeq Summary (NM_007441): This gene belongs to Group 1 of aristaless-like genes, which are characterized by the presence of an aristaless domain and a conserved paired-like homeodomain. The encoded protein acts as a transcriptional regulator. The protein plays a role in the development of craniofacial and appendicular skeleton and may have a role in pancreatic function. [provided by RefSeq, Apr 2013].
Gencode Transcript: ENSMUST00000014747.2
Gencode Gene: ENSMUSG00000014603.3
Transcript (Including UTRs)
   Position: mm10 chr3:107,595,031-107,605,776 Size: 10,746 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chr3:107,595,176-107,605,079 Size: 9,904 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:107,595,031-107,605,776)mRNA (may differ from genome)Protein (343 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Putative uncharacterized protein;
SUBCELLULAR LOCATION: Nucleus (By similarity).

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -76.80145-0.530 Picture PostScript Text
3' UTR -238.80697-0.343 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on Q3UQX2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0007389 pattern specification process
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0042981 regulation of apoptotic process
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  U96109 - Mus musculus proline-rich transcription factor ALX3 (Alx3) mRNA, complete cds.
AK142019 - Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230004L08 product:aristaless 3, full insert sequence.
BC141537 - Synthetic construct Mus musculus clone IMAGE:100014559, MGC:175422 aristaless-like homeobox 3 (Alx3) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_007441, Q3UQX2, Q3UQX2_MOUSE, uc008qxf.1, uc008qxf.2, uc008qxf.3
UCSC ID: uc008qxf.3
RefSeq Accession: NM_007441
Protein: Q3UQX2 CCDS: CCDS17739.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.