ID:PHX2A_MOUSE DESCRIPTION: RecName: Full=Paired mesoderm homeobox protein 2A; AltName: Full=Aristaless homeobox protein homolog; AltName: Full=PHOX2A homeodomain protein; AltName: Full=Paired-like homeobox 2A; FUNCTION: May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the paired homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 46689 - Homeodomain-like 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
ModBase Predicted Comparative 3D Structure on Q62066
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0003357 noradrenergic neuron differentiation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0021523 somatic motor neuron differentiation GO:0021623 oculomotor nerve formation GO:0021642 trochlear nerve formation GO:0021703 locus ceruleus development GO:0030901 midbrain development GO:0043576 regulation of respiratory gaseous exchange GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048485 sympathetic nervous system development GO:0048486 parasympathetic nervous system development
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