Mouse Gene Slc25a10 (ENSMUST00000026899.3) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 (Slc25a10), mRNA. (from RefSeq NM_013770)
Gencode Transcript: ENSMUST00000026899.3
Gencode Gene: ENSMUSG00000025792.9
Transcript (Including UTRs)
   Position: mm10 chr11:120,491,840-120,499,187 Size: 7,348 Total Exon Count: 11 Strand: +
Coding Region
   Position: mm10 chr11:120,491,987-120,498,175 Size: 6,189 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:120,491,840-120,499,187)mRNA (may differ from genome)Protein (287 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
ReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DIC_MOUSE
DESCRIPTION: RecName: Full=Mitochondrial dicarboxylate carrier; AltName: Full=Solute carrier family 25 member 10;
FUNCTION: Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed at very high levels in white adipocytes.
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D016604 Aflatoxin B1
  • D001564 Benzo(a)pyrene
  • D013749 Tetrachlorodibenzodioxin
  • D020122 tert-Butylhydroperoxide
  • C049325 1,2-dithiol-3-thione
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C023035 3,4,5,3',4'-pentachlorobiphenyl
  • C009505 4,4'-diaminodiphenylmethane
  • D015127 9,10-Dimethyl-1,2-benzanthracene
          more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -72.00147-0.490 Picture PostScript Text
3' UTR -428.301012-0.423 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002030 - Mit_uncoupling
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q9QZD8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015114 phosphate ion transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015117 thiosulfate transmembrane transporter activity
GO:0015131 oxaloacetate transmembrane transporter activity
GO:0015140 malate transmembrane transporter activity
GO:0015141 succinate transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015297 antiporter activity

Biological Process:
GO:0006817 phosphate ion transport
GO:0006839 mitochondrial transport
GO:0008272 sulfate transport
GO:0015709 thiosulfate transport
GO:0015729 oxaloacetate transport
GO:0015743 malate transport
GO:0015744 succinate transport
GO:0035435 phosphate ion transmembrane transport
GO:0071422 succinate transmembrane transport
GO:0071423 malate transmembrane transport
GO:1902356 oxaloacetate(2-) transmembrane transport
GO:1902358 sulfate transmembrane transport

Cellular Component:
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane


-  Descriptions from all associated GenBank mRNAs
  AK151645 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830032J12 product:solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10, full insert sequence.
AK083831 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130017L05 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 10, full insert sequence.
AK008038 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010002F14 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 10, full insert sequence.
AF188712 - Mus musculus mitochondrial dicarboxylate carrier mRNA, complete cds; nuclear gene for mitochondrial product.
AK050282 - Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730033M02 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 10, full insert sequence.
BC003222 - Mus musculus solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10, mRNA (cDNA clone MGC:7207 IMAGE:3482316), complete cds.
AK214910 - Mus musculus cDNA, clone:Y2G0133G01, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000026899, based on BLAT search.
AK213119 - Mus musculus cDNA, clone:Y2G0127D15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000026899, based on BLAT search.
AK008579 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010317L13 product:SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER; ADENINE NUCLEOTIDE TRANSLOCATOR), MEMBER 10, full insert sequence.
AK183869 - Mus musculus cDNA, clone:Y0G0127J17, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000026899, based on BLAT search.
AK210299 - Mus musculus cDNA, clone:Y2G0117P03, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000026899, based on BLAT search.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04964 - Proximal tubule bicarbonate reclamation

Reactome (by CSHL, EBI, and GO)

Protein Q9QZD8 (Reactome details) participates in the following event(s):

R-MMU-372843 malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]
R-MMU-1614546 Sulfate is exported to the cytosol in exchange for dicarboxylate
R-MMU-70263 Gluconeogenesis
R-MMU-428643 Organic anion transporters
R-MMU-1614517 Sulfide oxidation to sulfate
R-MMU-70326 Glucose metabolism
R-MMU-425374 Amino acid and oligopeptide SLC transporters
R-MMU-425393 Metabolism of nitrogenous molecules
R-MMU-1614558 Degradation of cysteine and homocysteine
R-MMU-71387 Metabolism of carbohydrates
R-MMU-425407 SLC-mediated transmembrane transport
R-MMU-1614635 Sulfur amino acid metabolism
R-MMU-1430728 Metabolism
R-MMU-382551 Transport of small molecules
R-MMU-71291 Metabolism of nitrogenous molecules

-  Other Names for This Gene
  Alternate Gene Symbols: Dic, DIC_MOUSE, NM_013770, Q543J6, Q99LJ9, Q9D8G8, Q9QZD8, uc007mtb.1, uc007mtb.2, uc007mtb.3
UCSC ID: uc007mtb.3
RefSeq Accession: NM_013770
Protein: Q9QZD8 (aka DIC_MOUSE)
CCDS: CCDS25738.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.