Mouse Gene Slc25a5 (ENSMUST00000016463.3) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 (Slc25a5), mRNA. (from RefSeq NM_007451)
RefSeq Summary (NM_007451): This gene encodes a transmembrane domain-containing protein that localizes to the mitochondrial inner membrane. The encoded protein facilitates the exchange of ADP from the cytoplasm with ATP from the mitochondria. Pseudogenes for this gene are found on multiple chromosomes. [provided by RefSeq, May 2015].
Gencode Transcript: ENSMUST00000016463.3
Gencode Gene: ENSMUSG00000016319.3
Transcript (Including UTRs)
   Position: mm10 chrX:36,795,651-36,798,807 Size: 3,157 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chrX:36,795,731-36,798,544 Size: 2,814 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:36,795,651-36,798,807)mRNA (may differ from genome)Protein (298 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q545A2_MOUSE
DESCRIPTION: SubName: Full=MCG11560; SubName: Full=Solute carrier family 25, member 5;
SIMILARITY: Belongs to the mitochondrial carrier family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.4080-0.192 Picture PostScript Text
3' UTR -53.90263-0.205 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002113 - Aden_trnslctor
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
101307 - YutG-like
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q545A2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0022857 transmembrane transporter activity
GO:0031625 ubiquitin protein ligase binding

Biological Process:
GO:0008284 positive regulation of cell proliferation
GO:0055085 transmembrane transport
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042645 mitochondrial nucleoid
GO:0043209 myelin sheath
GO:0045121 membrane raft
GO:0071817 MMXD complex


-  Descriptions from all associated GenBank mRNAs
  AK012750 - Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810016L04 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5, full insert sequence.
U27316 - Mus musculus adenine nucleotide translocase-2 (Ant2) mRNA, complete cds.
AK003467 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110005I11 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5, full insert sequence.
AK012751 - Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810016M09 product:SIMILAR TO SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER, ADENINE NUCLEOTIDE TRANSLOCATOR), MEMBER 5 homolog [Mus musculus], full insert sequence.
AK002283 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610007E16 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5, full insert sequence.
AK017881 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730593D02 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5, full insert sequence.
AK088730 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430024K03 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5, full insert sequence.
X70847 - M.musculus mRNA for adenine nucleotide translocase.
BC004570 - Mus musculus solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5, mRNA (cDNA clone MGC:8022 IMAGE:3586336), complete cds.
BC086756 - Mus musculus solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5, mRNA (cDNA clone MGC:101927 IMAGE:6818521), complete cds.
U10404 - Mus musculus adenine nucleotide translocase mRNA, complete cds.
AK195999 - Mus musculus cDNA, clone:Y1G0120F20, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000016463, based on BLAT search.
AK188826 - Mus musculus cDNA, clone:Y0G0146J12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000016463, based on BLAT search.
LF256896 - JP 2014500723-A/64399: Polycomb-Associated Non-Coding RNAs.
EF437333 - Mus musculus isolate NTA2D16 solute carrier family 25 member 5 (Slc25a5) mRNA, partial cds.
LF256894 - JP 2014500723-A/64397: Polycomb-Associated Non-Coding RNAs.
AK187088 - Mus musculus cDNA, clone:Y0G0139M15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000016463, based on BLAT search.
AK215039 - Mus musculus cDNA, clone:Y2G0133M06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000016463, based on BLAT search.
MA492473 - JP 2018138019-A/64399: Polycomb-Associated Non-Coding RNAs.
MA492471 - JP 2018138019-A/64397: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04020 - Calcium signaling pathway
mmu05012 - Parkinson's disease
mmu05016 - Huntington's disease

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_11560, NM_007451, Q545A2, Q545A2_MOUSE, RP23-286I5.1-001, uc009sxs.1, uc009sxs.2, uc009sxs.3
UCSC ID: uc009sxs.3
RefSeq Accession: NM_007451
Protein: Q545A2 CCDS: CCDS30062.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.