ID:UCP1_MOUSE DESCRIPTION: RecName: Full=Mitochondrial brown fat uncoupling protein 1; Short=UCP 1; AltName: Full=Solute carrier family 25 member 7; AltName: Full=Thermogenin; FUNCTION: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. SUBUNIT: Acts as a dimer forming a proton channel. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Brown adipose tissue. SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P12242
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002024 diet induced thermogenesis GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006811 ion transport GO:0006839 mitochondrial transport GO:0009266 response to temperature stimulus GO:0009409 response to cold GO:0031667 response to nutrient levels GO:0032870 cellular response to hormone stimulus GO:0034614 cellular response to reactive oxygen species GO:0050873 brown fat cell differentiation GO:0071398 cellular response to fatty acid GO:1902600 hydrogen ion transmembrane transport GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1990542 mitochondrial transmembrane transport GO:1990845 adaptive thermogenesis
AK002759 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610034P22 product:uncoupling protein 1, mitochondrial, full insert sequence. U63419 - Mus musculus mitochondrial uncoupling protein (Ucp) mRNA, nuclear gene encoding mitochondrial protein, complete cds. AK076454 - Mus musculus 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4833405B16 product:uncoupling protein 1, mitochondrial, full insert sequence. BC012701 - Mus musculus uncoupling protein 1 (mitochondrial, proton carrier), mRNA (cDNA clone MGC:13965 IMAGE:4191276), complete cds.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu03320 - PPAR signaling pathway mmu05016 - Huntington's disease
Reactome (by CSHL, EBI, and GO)
Protein P12242 (Reactome details) participates in the following event(s):
R-MMU-166220 FA anion diffuses laterally to UCP R-MMU-166387 The FA anion diffuses away laterally from UCP R-MMU-166214 FA anion flip-flops to the opposite surface R-MMU-170026 Protons are translocated from the intermembrane space to the matrix R-MMU-167826 The fatty acid cycling model R-MMU-166187 Mitochondrial Uncoupling Proteins R-MMU-167827 The proton buffering model R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport R-MMU-1430728 Metabolism
US Server
