Mouse Gene Slc25a26 (ENSMUST00000061118.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 (Slc25a26), mRNA. (from RefSeq NM_026255)
Gencode Transcript: ENSMUST00000061118.10
Gencode Gene: ENSMUSG00000045100.11
Transcript (Including UTRs)
   Position: mm10 chr6:94,500,331-94,604,672 Size: 104,342 Total Exon Count: 10 Strand: +
Coding Region
   Position: mm10 chr6:94,500,425-94,603,669 Size: 103,245 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:94,500,331-94,604,672)mRNA (may differ from genome)Protein (274 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: SAMC_MOUSE
DESCRIPTION: RecName: Full=S-adenosylmethionine mitochondrial carrier protein; AltName: Full=Mitochondrial S-adenosylmethionine transporter; AltName: Full=Solute carrier family 25 member 26;
FUNCTION: Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S- adenosylmethionine (SAM) into the mitochondria (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -24.6094-0.262 Picture PostScript Text
3' UTR -303.201003-0.302 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q5U680
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
     Gene Details
     Gene Sorter
 RGDEnsemblEnsemblWormBaseSGD
 Protein Sequence Protein SequenceProtein Sequence 
 Alignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0015805 S-adenosyl-L-methionine transport
GO:0055085 transmembrane transport
GO:1901962 S-adenosyl-L-methionine transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF195743 - JP 2014500723-A/3246: Polycomb-Associated Non-Coding RNAs.
AK015299 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930433D19 product:hypothetical Mitochondrial energy transfer proteins (carrier protein) containing protein, full insert sequence.
AK015954 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930533J15 product:hypothetical Mitochondrial energy transfer proteins (carrier protein) containing protein, full insert sequence.
BC037142 - Mus musculus solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26, mRNA (cDNA clone MGC:46774 IMAGE:5026631), complete cds.
BC019156 - Mus musculus solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26, mRNA (cDNA clone MGC:29269 IMAGE:5066084), complete cds.
BC049899 - Mus musculus solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26, mRNA (cDNA clone IMAGE:3967488).
MA431320 - JP 2018138019-A/3246: Polycomb-Associated Non-Coding RNAs.
BC037648 - Mus musculus solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26, mRNA (cDNA clone IMAGE:5251510), with apparent retained intron.
LF287073 - JP 2014500723-A/94576: Polycomb-Associated Non-Coding RNAs.
AK017037 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4933433F13 product:inferred: RIKEN cDNA 4933433F13 gene, full insert sequence.
LF287086 - JP 2014500723-A/94589: Polycomb-Associated Non-Coding RNAs.
LF287120 - JP 2014500723-A/94623: Polycomb-Associated Non-Coding RNAs.
MA522650 - JP 2018138019-A/94576: Polycomb-Associated Non-Coding RNAs.
MA522663 - JP 2018138019-A/94589: Polycomb-Associated Non-Coding RNAs.
MA522697 - JP 2018138019-A/94623: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5U680 (Reactome details) participates in the following event(s):

R-MMU-8855062 SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy
R-MMU-425393 Metabolism of nitrogenous molecules
R-MMU-425407 SLC-mediated transmembrane transport
R-MMU-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: NM_026255, Q5U680, Q8JZT2, Samc, SAMC_MOUSE, uc009czr.1, uc009czr.2, uc009czr.3, uc009czr.4
UCSC ID: uc009czr.4
RefSeq Accession: NM_026255
Protein: Q5U680 (aka SAMC_MOUSE)
CCDS: CCDS20379.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.