Mouse Gene Pax1 (ENSMUST00000109968.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired box 1 (Pax1), mRNA. (from RefSeq NM_008780)
Gencode Transcript: ENSMUST00000109968.2
Gencode Gene: ENSMUSG00000037034.16
Transcript (Including UTRs)
   Position: mm10 chr2:147,364,994-147,375,053 Size: 10,060 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr2:147,365,048-147,373,805 Size: 8,758 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:147,364,994-147,375,053)mRNA (may differ from genome)Protein (446 aa)
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-  Comments and Description Text from UniProtKB
  ID: PAX1_MOUSE
DESCRIPTION: RecName: Full=Paired box protein Pax-1;
FUNCTION: This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column.
SUBCELLULAR LOCATION: Nucleus.
DISEASE: Note=Undulated (un) homozygous mice exhibits vertebral malformations along the entire rostro-caudal axis. This is due to a single mutation in the paired box region.
SIMILARITY: Contains 1 paired domain.
SEQUENCE CAUTION: Sequence=AAA37793.1; Type=Erroneous gene model prediction; Sequence=AAA39888.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  mRNA Secondary Structure of 3' and 5' UTRs
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009057 - Homeodomain-like
IPR001523 - Paired_dom
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00292 - 'Paired box' domain
PF13384 - Homeodomain-like domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on P09084
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding

Biological Process:
GO:0001501 skeletal system development
GO:0001756 somitogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0007389 pattern specification process
GO:0008283 cell proliferation
GO:0009887 animal organ morphogenesis
GO:0043367 CD4-positive, alpha-beta T cell differentiation
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048538 thymus development
GO:0060017 parathyroid gland development
GO:0060349 bone morphogenesis
GO:0061056 sclerotome development

Cellular Component:
GO:0005634 nucleus
GO:0005667 transcription factor complex


-  Descriptions from all associated GenBank mRNAs
  AB080657 - Mus musculus Pax1 mRNA, partial cds, clone:5832438N23.
AB080656 - Mus musculus Pax1 mRNA, partial cds, clone:A430036B21.
AK134066 - Mus musculus adult male thymus cDNA, RIKEN full-length enriched library, clone:5830427P13 product:paired box gene 1, full insert sequence.
M69222 - Mouse Pax-1 protein (Pax-1) mRNA, complete cds.
BC140989 - Mus musculus paired box gene 1, mRNA (cDNA clone MGC:175950 IMAGE:9055601), complete cds.
AK041531 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630019K16 product:paired box gene 1, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: A2ALJ9, NM_008780, P09084, Pax-1, PAX1_MOUSE, Q9R2B1, uc008msx.1, uc008msx.2, uc008msx.3, uc008msx.4
UCSC ID: uc008msx.4
RefSeq Accession: NM_008780
Protein: P09084 (aka PAX1_MOUSE)
CCDS: CCDS16835.2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.