Mouse Gene Slc25a16 (ENSMUST00000044977.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 (Slc25a16), mRNA. (from RefSeq NM_175194)
Gencode Transcript: ENSMUST00000044977.9
Gencode Gene: ENSMUSG00000071253.8
Transcript (Including UTRs)
   Position: mm10 chr10:62,920,633-62,946,498 Size: 25,866 Total Exon Count: 9 Strand: +
Coding Region
   Position: mm10 chr10:62,920,752-62,944,471 Size: 23,720 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:62,920,633-62,946,498)mRNA (may differ from genome)Protein (332 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GDC_MOUSE
DESCRIPTION: RecName: Full=Graves disease carrier protein homolog; Short=GDC; AltName: Full=Mitochondrial solute carrier protein homolog; AltName: Full=Solute carrier family 25 member 16;
FUNCTION: Required for the accumulation of coenzyme A in the mitochondrial matrix (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.20119-0.447 Picture PostScript Text
3' UTR -520.302027-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002167 - Graves_DC
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q8C0K5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsembl  SGD
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK030865 - Mus musculus adult male thymus cDNA, RIKEN full-length enriched library, clone:5830435B21 product:GRAVE'S DISEASE CARRIER PROTEIN (GDC) (MITOCHONDRIAL SOLUTE CARRIER PROTEIN HOMOLOG) homolog [Bos taurus], full insert sequence.
BC062168 - Mus musculus solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16, mRNA (cDNA clone IMAGE:30133798), complete cds.
BC138983 - Mus musculus solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16, mRNA (cDNA clone MGC:170610 IMAGE:8862005), complete cds.
BC138984 - Mus musculus solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16, mRNA (cDNA clone MGC:170611 IMAGE:8862006), complete cds.
BC025015 - Mus musculus solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16, mRNA (cDNA clone IMAGE:3993106).
AK206376 - Mus musculus cDNA, clone:Y2G0104K15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000044977, based on BLAT search.
AK014068 - Mus musculus 13 days embryo head cDNA, RIKEN full-length enriched library, clone:3110021G18 product:inferred: Grave's disease carrier protein {Bos taurus}, full insert sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8C0K5 (Reactome details) participates in the following event(s):

R-MMU-199216 SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix
R-MMU-196783 Coenzyme A biosynthesis
R-MMU-199220 Vitamin B5 (pantothenate) metabolism
R-MMU-196849 Metabolism of water-soluble vitamins and cofactors
R-MMU-196854 Metabolism of vitamins and cofactors
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2RSS4, Gda, GDC_MOUSE, NM_175194, Q6P6K8, Q8C0K5, uc007fjh.1, uc007fjh.2
UCSC ID: uc007fjh.2
RefSeq Accession: NM_175194
Protein: Q8C0K5 (aka GDC_MOUSE)
CCDS: CCDS23893.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.