ID:RX_MOUSE DESCRIPTION: RecName: Full=Retinal homeobox protein Rx; AltName: Full=Retina and anterior neural fold homeobox protein; FUNCTION: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in the photoreceptor and inner nuclear layers. DEVELOPMENTAL STAGE: Strongly expressed in anterior neural plate at E8.5, followed in optic sulci and ventral forebrain at E9.0, and in eye at E10.5 uniformly expressed in neuroretina at E15.5, and at later stages, expression decreases. SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O35602
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007389 pattern specification process GO:0007420 brain development GO:0021854 hypothalamus development GO:0043010 camera-type eye development GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0060173 limb development
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